Injectable immunoregulatory hydrogels sequentially drive phenotypic polarization of macrophages for infected wound healing.

Regulating macrophage phenotypes to reconcile the conflict between bacterial suppression and tissue regeneration is ideal for treating infectious skin wounds. Here, an injectable immunoregulatory hydrogel (SrmE20) that sequentially drives macrophage phenotypic polarization (M0 to M1, then to M2) was constructed by integrating anti-inflammatory components and proinflammatory solvents. experiments demonstrated that the proinflammatory solvent ethanol stabilized the hydrogel structure, maintained the phenolic hydroxyl group activity, and achieved macrophages' proinflammatory transition (M0 to M1) to enhance antibacterial effects.

Isomer engineering for deep understanding of aggregation-induced photothermal enhancement in conjugated systems.

Organic photothermal materials based on conjugated structures have significant potential applications in areas such as biomedical diagnosis, therapy, and energy conversion. Improving their photothermal conversion efficiency through molecular design is critical to promote their practical applications. Especially in similar structures, understanding how the position of heteroatoms affects the conversion efficiency is highly desirable.

Quaternization of a Triphenylamine-Based Conjugated Porous Organic Polymer to Immobilize PtCl for the Photocatalytic Reduction of 4-Nitrophenol.

Photocatalytic reduction of 4-nitrophenol (4-NP) for converting it to nontoxic 4-aminophenol (4-AP) is one of the most efficient approaches for removing toxic 4-NP. Using porous organic polymers (POPs) as the support to immobilize noble metal catalysts has exhibited remarkable reduction performance but is rarely reported. Herein, a cationic triphenylamine-based POP was synthesized by quaternization to immobilize PtCl to prepare an efficient photocatalyst named DCM-TPA-Pt for the reduction of 4-NP to 4-AP in the presence of NaBH.

Visible-Light-Promoted Cascade Carboxylation/Arylation of Unactivated Alkenes with CO for the Synthesis of Carboxylated Indole-Fused Heterocycles.

Described here is a visible-light-promoted cascade carboxylation/arylation of indole-tethered unactivated alkenes with CO to access various carboxylated indole-fused heterocycles. This reaction is initiated by the addition of a CO radical anion to the alkene motif toward an alkyl carbon radical, followed by its addition to the aromatic ring, and then rearomatization to afford the final products. This reaction provides a facile and sustainable protocol for the construction of carboxylated indole-fused heterocycles using CO as the carboxylic source.

A near-infrared-II light-response BODIPY-based conjugated microporous polymer for enhanced photocatalytic degradation of cationic dyes and HO production.

A BODIPY-containing conjugated microporous polymer (CMP, LBFD-1) was modified with calixarene to develop a hydrophilic CMP (LBFD-2) with broader absorption extending to the near-infrared-II region. LBFD-2 exhibited an HO production rate of 2.14 mmol g h in the air without any sacrificial agents.

Trifunctional phosphorus-doped cobalt molybdate catalyst in self-driven coupling systems for synchronized sulfur recovery and hydrogen evolution.

This study introduces a self-driven system that effectively achieves synchronized sulfur recovery and hydrogen production using a Zn-air battery. The system ingeniously integrates the sulfur oxidation reaction (SOR) and the hydrogen evolution reaction (HER) into a single, efficient process. Central to this system is the trifunctional phosphorus-doped cobalt molybdate catalyst (P-CoMoO/NF), which exhibits superior performance in both HER (η = 0.

Synthesis of tetraphenylethylene-based small molecular sensor for the selective "turn-on" detection of pyrophosphoric acid in the aqueous solution.

Pyrophosphoric acid (PPi) is a crucial indicator for monitoring adenosine triphosphate hydrolysis processes, and abnormal PPi levels in the human body seriously threaten human health. Thus the efficient detection of the concentration of PPi in the aqueous solution is important and urgent. This paper described the successful synthesis of a tetraphenylethylene (TPE) derivative, named as TPE-4B, which contained four chelate pyridinium groups exhibiting aggregation-induced emission characteristics.

Hierarchical Scaffold with Directional Microchannels Promotes Cell Ingrowth for Bone Regeneration.

Bone regenerative scaffolds with a bionic natural bone hierarchical porous structure provide a suitable microenvironment for cell migration and proliferation. Here, a bionic scaffold (DP-PLGA/HAp) with directional microchannels is prepared by combining 3D printing and directional freezing technology. The 3D printed framework provides structural support for new bone tissue growth, while the directional pore embedded in the scaffolds provides an express lane for cell migration and nutrition transport, facilitating cell growth and differentiation.

Construction active sites in nickel sulfide by dual-doping vanadium/cobalt for highly effective oxygen evolution reaction.

Rational design and exploration of oxygen evolution reaction (OER) electrocatalysts with exceptional performance are crucial for the advancement of the hydrogen energy economy. In this study, vanadium/cobalt (V/Co) dual-doped nickel sulfide (NiS) nanowires were synthesized on a nickel foam (NF) substrate to overcome the sluggish kinetics typically associated with OER. The resulting catalyst exhibited outstanding electrocatalytic activity towards OER in a 1.

Using Aggregation to Chaperone Nanoparticles Across Fluid Interfaces.

Nanoparticles (NPs) transfer is usually induced by adding ligands to modify NP surfaces, but aggregation of NPs oftentimes hampers the transfer. Here, we show that aggregation during NP phase transfer does not necessarily result in transfer failure. Using a model system comprising gold NPs and amphiphilic polymers, we demonstrate an unusual mechanism by which NPs can undergo phase transfer from the aqueous phase to the organic phase via a single-aggregation-single pathway.

Dual-Cross-Linked Magnetic Hydrogel with Programmed Release of Parathyroid Hormone Promotes Bone Healing.

Intermittent delivery of parathyroid hormone (PTH) could effectively promote bone regeneration, but the need for daily injection administration has limited its further clinical applications. Exposure to magnetic stimulation could regulate cell fate to promote osteogenesis. Herein, we developed a magnetized hydrogel with programmed PTH release and simultaneous magnetic actuation to promote osteogenic commitment.

D-A-Type Molecules with Free Rotors for Highly Efficient Interfacial Solar-Driven Steam Generation and Thermoelectric Performance.

Three "π"-shaped D-A-type thiodiazoloquinoxaline derivatives with different electronic structures and rotations have been prepared. Their particular structures allow these molecules to possess a broad absorption range and sufficient intramolecular motions, dissipating energy through a thermal deactivation pathway. Among the three materials, showed the best steam generation efficiency (84.

Fluorination of naphthalimide-cyanostilbene derivatives to achieve dual-state emission luminogens with strong fluorescence in highly polar environments for bioimaging.

Organic luminogens (OLs) that emit strong fluorescence in both solution and the aggregated state, referred to as dual-state emission luminogens (DSEgens), are highly desirable because of their capability to achieve multiple functions within onefold materials. The fluorescence of OLs, including DSEgens, with intramolecular charge transfer characteristics, often decreases in solution as the solvent polarity increases, namely the positive solvatokinetic effect, resulting in inferior environmental stability. In this work, fluorination to naphthalimide (NI)-cyanostilbene (CS) derivatives was adopted to construct novel DSEgens (NICSF-X, X = B, P, M, and T, respectively).

Stabilizing Liquids Using Interfacial Supramolecular Assemblies.

Stabilizing liquids based on supramolecular assembly (non-covalent intermolecular interactions) has attracted significant interest, due to the increasing demand for soft, liquid-based devices where the shape of the liquid is far from the equilibrium spherical shape. The components comprising these interfacial assemblies must have sufficient binding energies to the interface to prevent their ejection from the interface when the assemblies are compressed. Here, we highlight recent advances in structuring liquids based on non-covalent intermolecular interactions.

Structural Engineering of Red Luminogens to Realize High Emission Efficiency through ACQ-to-AIE Transformation.

Deep red/near-infrared (NIR, >650 nm) emissive organic luminophores with aggregation-induced emission (AIE) behaviours have emerged as promising candidates for applications in optoelectronic devices and biological fields. However, the molecular design philosophy for AIE luminogens (AIEgens) with narrow band gaps are rarely explored. Herein, we rationally designed two red organic luminophores, FITPA and FIMPA, by considering the enlargement of transition dipole moment in the charge-transfer state and the transformation from aggregation-caused quenching (ACQ) to AIE.

Covalently Grafted Biomimetic Matrix Reconstructs the Regenerative Microenvironment of the Porous Gradient Polycaprolactone Scaffold to Accelerate Bone Remodeling.

Integrating a biomimetic extracellular matrix to improve the microenvironment of 3D printing scaffolds is an emerging strategy for bone substitute design. Here, a "soft-hard" bone implant (BM-g-DPCL) consisting of a bioactive matrix chemically integrated on a polydopamine (PDA)-coated porous gradient scaffold by polyphenol groups is constructed. The PDA-coated "hard" scaffolds promoted Ca chelation and mineral deposition; the "soft" bioactive matrix is beneficial to the migration, proliferation, and osteogenic differentiation of stem cells in vitro, accelerated endogenous stem cell recruitment, and initiated rapid angiogenesis in vivo.

Urea-oxidation-assisted electrochemical water splitting for hydrogen production on a bifunctional heterostructure transition metal phosphides combining metal-organic frameworks.

Electrocatalyzed urea-assisted wastewater splitting is a promising approach for sustainable hydrogen production. However, the lack of cost-efficient electrocatalysts hinders its practical application. Herein, bimetal phosphide (NiCoP) nanowire arrays decorated with ultrathin NiFeCo metal-organic framework (NiFeCo-MOF) nanosheets on porous nickel foam (NF) were designed for urea-assisted wastewater splitting.

Tailorable 3DP Flexible Scaffolds with Porosification of Filaments Facilitate Cell Ingrowth and Biomineralized Deposition.

Facilitating cell ingrowth and biomineralized deposition inside filaments of 3DP scaffolds are an ideal bone repair strategy. Here, 3D printed PLGA/HA scaffolds with hydroxyapatite content of 50% (P5H5) and 70% (P3H7) were prepared by optimizing 3D printing inks, which exhibited good tailorability and foldability to meet clinical maneuverability. The supercritical CO foaming technology further endowed the filaments of P5H5 with a richer interconnected pore structure (P5H5-C).

Visualizing Assembly Dynamics of All-Liquid 3D Architectures.

To better exploit all-liquid 3D architectures, it is essential to understand dynamic processes that occur during printing one liquid in a second immiscible liquid. Here, the interfacial assembly and transition of 5,10,15,20-tetrakis(4-sulfonatophenyl) porphyrin (H TPPS) over time provides an opportunity to monitor the interfacial behavior of nanoparticle surfactants (NPSs) during all-liquid printing. The formation of J-aggregates of H TPPS at the interface and the interfacial conversion of the J-aggregates of H TPPS to H-aggregates of H TPPS is demonstrated by interfacial rheology and in situ atomic force microscopy.

Continuous, autonomous subsurface cargo shuttling by nature-inspired meniscus-climbing systems.

Water-walking insects can harness capillary forces by changing their body posture to climb or descend the meniscus between the surface of water and a solid object. Controlling surface tension in this manner is necessary for predation, escape and survival. Inspired by this behaviour, we demonstrate autonomous, aqueous-based synthetic systems that overcome the meniscus barrier and shuttle cargo subsurface to and from a landing site and a targeted drop-off site.

SuFEx modification of silk fibroin silicon aerogel and its adsorption behavior and antibacterial performance.

A silk fibroin silicon-based composite aerogel (SSA) has been modified via a SuFEx reaction for application in the adsorption of anionic pollutants and antimicrobials in water. The tyrosine fragment in the silk fibroin was modified by a high yielding SuFEx click reaction. A quaternary ammonium salt functionality was introduced into the silk fibroin protein and the modified silk fibroin protein was crosslinked with tetraethyl orthosilicate.

Side-Chain Type Polysulfates: Their Synthesis, AIE Properties and Applications for p-Nitrophenol Detection in Water.

Two small molecular monomers, ph-TPE and ph-TPE-CN, and their homopolymers Poly (ph-TPE) and Poly (ph-TPE-CN) containing tetra phenylethylene and sulfate structures, were synthesized by a sulfur (VI) fluorine exchange click reaction (SuFEx) and radical polymerization. All the monomers and polymers exhibit a typical aggregation-induced emission (AIE) effect both in the solid state and aggregated state. Moreover, based on the intermolecular charge transfer (ICT) effect between the tetra phenylethylene chromophore and p-nitrophenol, both polymers could be used for the selective detection of p-nitrophenol.

Unexpected organic hydrate luminogens in the solid state.

Developing organic photoluminescent materials with high emission efficiencies in the solid state under a water atmosphere is important for practical applications. Herein, we report the formation of both intra- and intermolecular hydrogen bonds in three tautomerizable Schiff-base molecules which comprise active hydrogen atoms that act as proton donors and acceptors, simultaneously hindering emission properties. The intercalation of water molecules into their crystal lattices leads to structural rearrangement and organic hydrate luminogen formation in the crystalline phase, triggering significantly enhanced fluorescence emission.