Publications by authors named "Peiyan Cai"
Colistin, also known as polymyxin E, is a lipopeptide antibiotic used to treat infections caused by multidrug-resistant gram-negative bacteria. It is considered a "last-line antibiotic", but its clinical development is hindered by low titer and impurities resulting from the presence of diverse homologs in microbial fermentation. To ensure consistent pharmaceutical activity and kinetics, it is crucial to have high-purity colistin active pharmaceutical ingredient (API) in the pharmaceutical industry.
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- LAB produce bioactive metabolites that may help maintain microbiome health, but their full potential and role in the human microbiome are not well understood.
- Research analyzed over 31,000 LAB genomes and identified over 130,000 gene clusters associated with secondary metabolites, revealing a variety of strain-specific and characteristic compounds.
- Findings show that LAB-derived substances, particularly class II bacteriocins, are abundant in vaginal microbiomes and may play a protective role by regulating microbial communities, suggesting their significance in maintaining microbiome balance.
Thiosulfate oxidation by microbes has a major impact on global sulfur cycling. Here, we provide evidence that bacteria within various Roseobacter lineages are important for thiosulfate oxidation in marine biofilms. We isolate and sequence the genomes of 54 biofilm-associated Roseobacter strains, finding conserved sox gene clusters for thiosulfate oxidation and plasmids, pointing to a niche-specific lifestyle.
View Article and Find Full Text PDFBacterial natural product biosynthetic genes, canonically clustered, have been increasingly found to rely on hidden enzymes encoded elsewhere in the genome for completion of biosynthesis. The study and application of lanthipeptides are frequently hindered by unclustered protease genes required for final maturation. Here, we establish a global correlation network bridging the gap between lanthipeptide precursors and hidden proteases.
View Article and Find Full Text PDFPlasmid-mediated quinolone resistance (PMQR) remains one of the main mechanisms of bacterial quinolone resistance and plays an important role in the transmission of antibiotic resistance genes (ARGs). In this study, two novel plasmids, p3M-2A and p3M-2B, which mediate quinolone resistance in strain 3M (P3M) were identified. Of these, only p3M-2B appeared to be a -carrying plasmid.
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