Daily and Peak Monitor Independent Movement Summary (MIMS) Values Associated With Metabolic Syndrome: NHANES 2011-12 and 2013-14.

The U.S. National Health and Nutrition Examination Survey (NHANES) physical activity monitor datasets for 2011-12 and 2013-14 were released in late 2020.

Vascular function in multiple sclerosis: Systematic review with meta-analysis.

Background: Vascular comorbidities are prevalent in persons with multiple sclerosis (MS), yet less is known about underlying vascular function (VF). We performed a systematic review with meta-analysis of studies that compared VF in persons with MS and healthy controls and examined factors that may moderate the difference in vascular outcomes between groups.

Methods: We conducted a systematic search using PubMed/MEDLINE, CINAHL, and Embase from inception through March 2024.

Remotely-delivered exercise training program for improving physical and cognitive functions among older adults with multiple sclerosis: Protocol for an NIH stage-I randomized controlled trial.

Background: Older adults with multiple sclerosis (MS) present with low physical activity participation, cognitive and ambulatory dysfunctions, and compromised quality of life (QOL).

Objective: We propose a NIH Stage-I, randomized controlled trial (RCT) that examines the feasibility and efficacy of a 16-week theory-based, remotely-delivered, exercise training program for improving cognitive and physical functions in older adults with MS who have moderate mobility disability without severe cognitive impairment.

Methods: This Stage-I study utilizes a parallel-group RCT design.

Acute Effects of Cadence-Controlled Walking on Cognition and Vascular Function in Physically Inactive Older Adults: A Randomized Crossover Study.

Background: Cadence-controlled walking may be a desirable approach for older adults to self-monitor exercise intensity and achieve physical activity guidelines. We examined the acute effects of cadence-controlled walking on cognition and vascular function in physically inactive older adults.

Methods: In a randomized crossover design, 26 participants (65% females, 67.

Drop-out, adherence, and compliance in randomized controlled trials of exercise training in multiple sclerosis: Short report.

We documented reporting and rates of drop-out, adherence, and compliance from 40 randomized controlled trials (RCTs) included in our meta-analysis on safety of exercise training (ET) in MS. We adopted definitions and metrics of adherence and compliance provided by the MoXFo adherence group. Drop-out was reported in 100% of the RCTs and approximated 10% for intervention and control conditions.

Free-living ambulatory physical activity and cognitive function in multiple sclerosis: the significance of step rate vs. step volume.

Background: Physical activity (PA) represents a promising behavioral approach for managing cognitive dysfunction in multiple sclerosis (MS). However, there is a lack of information on the pattern of free-living PA intensity (e.g.

Systematic review and meta-analysis of sedentary behavior in persons with multiple sclerosis.

Background: Persons with multiple sclerosis (MS) engage in less physical activity than the general population, and the disease manifestations and comorbidity conditions might further predispose them toward sedentary behavior (SB) among this population. We performed a systematic review with meta-analysis of studies that compared SB in persons with MS and non-MS controls, and examined factors that may moderate the difference in SB between the two groups.

Methods: We conducted a systematic search using PubMed, PsycINFO, Scopus, and CINAHL from inception up to August 2022, and identified studies that involved group comparison of SB outcomes between MS and non-MS controls.

Free-Living Peak Cadence in Multiple Sclerosis: A New Measure of Real-World Walking?

Background: Physical function and walking performance have become important outcomes in clinical trials and rehabilitation involving persons with multiple sclerosis (MS). However, assessments conducted in controlled settings may not reflect real-world capacity and movement in a natural environment. Peak cadence via accelerometry might represent a novel measure of walking intensity and prolonged natural effort under free-living conditions.

CD300ld on neutrophils is required for tumour-driven immune suppression.

The immune-suppressive tumour microenvironment represents a major obstacle to effective immunotherapy. Pathologically activated neutrophils, also known as polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), are a critical component of the tumour microenvironment and have crucial roles in tumour progression and therapy resistance. Identification of the key molecules on PMN-MDSCs is required to selectively target these cells for tumour treatment.

Effects of aerobic, resistance, and combined exercise training on health-related quality of life in multiple sclerosis: Systematic review and meta-analysis.

Background: Multiple sclerosis (MS) is an immune-mediated, neurodegenerative disease of the central nervous system that manifests in symptoms that compromise health-related quality of life (HRQOL). HRQOL focuses on a person's overall, subjective evaluation of health status primarily in the physical and mental domains. Exercise training is a form of rehabilitation for managing MS-related outcomes that might influence HRQOL.

Vascular function and cognition in persons with multiple sclerosis: Preliminary examination.

Background: Cognitive dysfunction is one of the most common consequences of multiple sclerosis (MS). Recent studies have noted a high incidence of vascular comorbidity that might be associated with cognitive decline among persons with MS. However, there is a lack of evidence on vascular biomarkers (e.

Validity of the 30-Second Sit-to-Stand test as a measure of lower extremity function in persons with multiple sclerosis: Preliminary evidence.

Background: The 30-Second Sit-To-Stand (30SSTS) is a quick, inexpensive, safe, and widely used clinical measure of lower extremity function. To date, there is limited evidence regarding the use of 30SSTS in multiple sclerosis (MS). The purpose of this study was to examine the construct validity of the 30SSTS test in persons with MS compared with non-MS healthy controls.

Cadence-based classification of moderate-intensity overground walking in 41- to 85-year-old adults.

Background: Walking cadence (steps/min) has emerged as a valid proxy of physical activity intensity, with consensus across numerous laboratory-based treadmill studies that ≥100 steps/min approximates absolutely defined moderate intensity (≥3 metabolic equivalents; METs). We recently reported that this cadence threshold had a classification accuracy of 73.3% for identifying moderate intensity during preferred pace overground walking in young adults.

Health and Fitness Comparisons Among Middle-Aged and Older Adults with Long-Term Participation in Four Different Sports.

Physical activity is known to confer numerous health benefits. However, few studies have assessed the prolonged impact of participation in different sports on health and fitness. The purpose of this cross-sectional study was to compare the impact of long-term participation (i.

Microblog data analysis of emotional reactions to COVID-19 in China.

To explore the emotional attitudes of microblog users in the different COVID-19 stages in China, this study used data mining and machine-learning methods to crawl 112,537 Sina COVID-19- related microblogs and conduct sentiment and group difference analyses. It was found that: (1) the microblog users' emotions shifted from negative to positive from the second COVID-19 pandemic phase; (2) there were no significant differences in the microblog users' emotions in the different regions; (3) males were more optimistic than females in the early stages of the pandemic; however, females were more optimistic than males in the last three stages; and (4) females posted more microblogs and expressed more sadness and fear while males expressed more anger and disgust. This research captured online information in real-time, with the results providing a reference for future research into public opinion and emotional reactions to crises.

Classification of moderate-intensity overground walking speed in 21- to 85-year-old adults.

The Compendium of Physical Activities reports that walking at 2.5 mph associates with absolutely-defined moderate intensity (i.e.

Dose-Response Association Between Physical Activity (Daily MIMS, Peak 30-Minute MIMS) and Cognitive Function Among Older Adults: NHANES 2011-2014.

Background: The purpose of this study was to determine the dose-response association between habitual physical activity (PA) and cognitive function using a nationally representative data set of U.S. older adults aged ≥60 years.

Mass quarantine and mental health during COVID-19: A meta-analysis.

Unlabelled: To reveal the complex relationships between quarantine and mental health during COVID-19, a meta-analysis was conducted involving 34 articles and a total sample size of 134,061. As the relationship between quarantine and mental health was found to be affected by the sampling objects and national factors, a random-effects model was applied for the meta-analysis. First, a heterogeneity test and sensitivity analysis were conducted to determine whether there was heterogeneity in the samples, after which a funnel chart, Rosenthal's Classic Fail-safe N test and Egger's test were applied to further determine whether there was publication bias in the included samples.