TFAP2B governs the regulation of SIRT1 to inhibit osteoclast-induced bone destruction.

Background: Cholesteatoma is a benign epithelial lesion that affects the middle ear or mastoid process, causing otorrhea and hearing impairment. Currently, the pathogenesis of temporal bone injury in middle ear cholesteatoma remains elusive, hindering the development of effective treatment strategies.

Methods And Results: We examined the expression of transcription factor AP-2-beta (TFAP2B) and its downstream factor silent mating type information regulation 2 homolog 1 (SIRT1) in clinical samples from patients with middle ear cholesteatoma and analyzed the potential correlation between TFAP2B expression and clinical conditions.

Spatio-temporal Analysis of Anthropogenic Disturbances on Landscape Pattern of Tourist Destinations: a case study in the Li River Basin, China.

The impact of human-related activities on the eco-environment of tourist destinations is an important part of recreation ecology research. However, traditional studies have mainly concentrated on the static influences upon the simple factors of soil or vegetation in tourist destinations, and the relationship between anthropogenic disturbances and landscape patterns is little understood. In this study, we constructed a disturbance model on a landscape scale to identify and quantify the main anthropogenic disturbances.

An analytical model for contaminant transport in landfill composite liners considering coupled effect of consolidation, diffusion, and degradation.

One-dimensional mathematical model is developed to investigate the behavior of contaminant transport in landfill composite liner system considering coupled effect of consolidation, diffusion, and degradation. The first- and second-type bottom boundary conditions are used to derive the steady-state and quasi-steady-state analytical solutions. The concentration profiles obtained by the proposed analytical solution are in good agreement with those obtained by the laboratory tests.