Epoxy-based multifunctional re-bondable polymer with self-healing, shape memory and superb bonding properties.

Thermoset epoxy resin-based materials are widely used, but their permanent cross-linked network limits their processability and reusability, which can lead to environmental burdens. In this work, by exploiting the weak reactivity of aniline to design appropriate reaction ratios, we achieved a linear link between the epoxy resin and the curing agent. This linear link, along with the crosslinking points provided by the flexibly branched polyurethanes, avoids the inherent brittleness associated with the highly crosslinked network of conventional epoxy resins.

Asynchronous Ring Opening of Cyclic Carbonate and Glycidyl Ether Induced Phase Evolution Towards Heat-Free and Rapid-Bonding Superior Epoxy Adhesive.

Structural adhesives that do not require heating are in high demand in the automotive and electronics industries. However, it remains a challenge to develop robust adhesives that rapidly achieve super adhesion near ambient temperature. Herein, a room-temperature curable, fast-bonding, and super strong epoxy-based structural adhesive was designed from the perspective of cross-scale structure, which lies in threefold pivotal aspects: (i) high branching topology of glycerol carbonate-capped polyurethane (PUGC) increases the kinetics of the ring-opening reaction, contributing to fast crosslinking and the formation of abundant urethane and hydroxyl moieties; (ii) asynchronous crosslinking of epoxy and PUGC synergistically induces phase separation of PUGC within the epoxy resin and the resulting PUGC domains surrounded by interpenetrated shell serves to efficiently toughen the matrix; (iii) abundant dynamic hydrogen bonds including urethane and hydroxyl moieties, along with the elastomeric PUGC domains, dissipate energy of shearing force.

Application of Fluorescent Probes in Reactive Oxygen Species Disease Model.

Reactive oxygen species (ROS) play an important role in living activities as signaling molecules that regulate the living activities of organisms. There are many types of ROS, mainly including hydrogen peroxide (HO), hypochlorous acid (HOCl), hydroxyl radical (•OH), peroxyl radical (ROO•), singlet oxygen (O), peroxynitrite (ONOO) and superoxide anion radical (O•) etc. Existing studies have shown that changes in ROS levels are closely associated with the development of many diseases, such as inflammation, cancer, cardiovascular disease, and neurodegenerative damage.

Dual-Ratiometric Fluorescent Probe for HO and HClO in Living Cells and Zebrafish and Application in Alcoholic Liver Injury Monitoring.

Reactive oxygen species (ROS) are an important component for maintaining normal physiological activities in organisms, and abnormal changes in their level are often accompanied by many diseases. As the two most representative components of ROS, HClO and HO play vital roles in many physiological and pathological processes and are interdependent and mutually transformable. Although there is a lot of work that has specifically detected HClO or HO, there are few reports on the simultaneous differential detection of HClO and HO.

A phenothiazine coumarin based ratiometric fluorescent probe for real-time detection of lysosomal hypochlorite in living cell and zebra fish.

Hypochlorite (ClO), a type of reactive oxygen species (ROS), plays an essential role in complex biological systems. Real-time detection of the content and distribution of ClO in cells or subcellular organelle is critically essential. In this paper, a lysosomal-targeted fluorescent probe, Cou-Lyso, was constructed for real-time detection of ClO in a ratiometric manner, achieving high sensitivity with a low detection limit (0.

A bifunctional fluorescent probe for simultaneous detection of GSH and HS (n > 1) from different channels with long-wavelength emission.

In this work, we presented a long-wavelength emission fluorescent probe DCM-Cou-SePh that can discriminatively detect glutathione (GSH) and hydrogen polysulfides (HS, n > 1) from green and red emission channels, respectively. With the addition of GSH, probe DCM-Cou-SePh displayed green fluorescence emission (λ = 430/530 nm). In the presence of HS, the probe exhibited a significant fluorescence enhancement in red channel (λ = 560/680 nm).