The dual missions of FoxO3a in inflammatory diseases: Regulation of antioxidant enzymes and involvement in programmed cell death.

The transcription factor FoxO3a plays a crucial role in the process of cells adapting to various stress conditions. Multiple post - translational modifications and epigenetic mechanisms work together to precisely regulate the activity of FoxO3a, influencing its subcellular localization, stability, interactions with other proteins, DNA - binding affinity, and transcriptional regulatory capacity. Under different chemical signal stimuli and subcellular environments, the activation of FoxO3a triggered by oxidative stress can initiate diverse transcriptional programs, which are essential for the body to resist oxidative damage.

Selective extraction of zearalenone from corn steep liquor for raw material of standard substance using polyamide membrane.

Zearalenone (ZEN) is one of the most prevalent mycotoxins in corn and its products, which can accumulate in corn steep liquor (CSL) with much higher concentration after deep processing. For ensuring the precision of ZEN analysis in food safety, ZEN standard substance is critical. However, the preparation of standard substance usually needs complex chemical synthesis steps and large amounts of organic solvents consumption.

Zinc-selenium interaction regulates leaf photosynthesis and mediates grain sugar metabolism to improve the yield and quality of hybrid rice: A physiological perspective.

As a fundamental food crop on a global scale, rice necessitates continual focus on improving both its yield and quality. This study investigates the regulatory effects of zinc and selenium, two beneficial elements, on rice quality and yield formation, with a particular emphasis on their impact on photosynthetic physiology throughout the rice growth cycle. The findings indicate that the interaction between zinc and selenium enhances the net photosynthetic rate of rice leaves, primarily by modulating stomatal movement.

The application of emerging technologies for the quality and safety evaluation of oilseeds and edible oils.

Oilseeds and edible oils are an indispensable part for the human diet and provide nutritional support for the human health. It has been reported a total of above 170 million tons per annum of edible oils consumption were consumed worldwide. Safety and quality of oilseeds and edible oils cannot be ignored, which can pose risk to human health and cause agro-economic loss.

Catalytic boost in dual-active sites hierarchical hollow nanozymes: An enhanced robust and sensitive immunochromatographic assay for Aspergillus flavus.

The practical application of nanozyme-mediated Point-of-Care Testing (POCT) is always constrained by insufficient sensitivity, slow development time, and limited robustness. Here, we developed a dual-active site hierarchical hollow CuS@MIL-100(Fe) (CuS@MIL) nanozyme through an easy-to-operate process. The resultant CuS@MIL nanozyme exhibited a 5- and 3-fold increase in catalytic efficiency relative to CuS and MIL-100, while the color development time was shortened by more than 6-fold.

Aspergillus Mycotoxins: The Major Food Contaminants.

Mycotoxins, a category of fungal secondary metabolites, frequently contaminate food products and pose a severe threat to human health. Aspergillus, a genus of fungi, is capable of producing mycotoxins, with aflatoxins (AFs) and ochratoxins being its principal types. Aspergillus mycotoxins can contaminate a wide range of crops and their derivatives, such as maize, wheat, rice, minor cereals, and peanuts, thereby threatening food and feed safety.

Arthroscopic-assisted uniportal spinal surgery for treatment of lumbar burst fractures complicated with neurological symptoms: a case report.

Lumbar burst fractures account for 21% to 58% of all thoracolumbar fractures. L5 lumbar burst fractures are rare, comprising 1.2% of spinal burst fractures.

Multifunctional metal-organic frameworks-mediated colorimetric/photothermal immunosensor for highly sensitivity detection of dibutyl phthalate.

Dibutyl phthalate (DBP), a priority pollutant among phthalic acid esters (PAEs) exhibits significant reproductive and respiratory toxicity. In this study, a multifunctional metal-organic frameworks-mediated colorimetric/photothermal immunosensor was established for the quantitative detection of DBP. Firstly, a highly sensitive and specific monoclonal antibody (mAb), designated 3A5, was prepared with a sensitivity IC value of 16.

Genetically engineered integrated aflatoxin B and deoxynivalenol bispecific nanobody as surrogate antigens for constructed time-resolved immunoassay dual detection methods.

There is a phenomenon of combined contamination of fungal toxins, of which aflatoxin B (AFB) is the most toxic, and deoxynivalenol (DON) contamination is common. The use of antigens for double or multiple testing of mycotoxins is easy to cause environmental pollution, and surrogate antigens have become necessary. The small molecule and susceptibility to genetic modification of nanobodies can be used to develop alternative antigens for mycotoxins.

Simultaneous analysis of PAEs in edible oil and dietary exposure assessment in Hubei.

Phthalic acid esters (PAEs), widely used in food processing, pose significant risks to food safety and human health. A rapid and accurate method to simultaneously detect 18 PAEs in edible oil was developed and applied to evaluate daily exposures in Hubei. By using ultrasound-assisted extraction and GC-MS with deuterated isotopes, we improved extraction efficiency and detection accuracy.

Time-resolved fluorescence/visual dual-readout nanobiosensors for the detection of aflatoxin B, benzo(α)pyrene and capsaicin in edible oils using a miniaturized paper analytical device.

Edible oil safety impacts food safety and consumer health. The typical pollutants-aflatoxin B (AFB) and benzo(α)pyrene (BaP), and kitchen waste oil-are significant hazards in edible oil consumption. Herein, we developed a dual-readout lateral flow immunoassay (tdLFIA) for the multi-quantitative detection of AFB, BaP and capsaicin (CAP).

Evaluation of phenolics in the analysis of virgin olive oil using near infrared spectroscopy.

Olive oil is an indispensable part of the diet in Mediterranean regions, and is appreciated worldwide for its sensory characteristics, combining a fine aroma and pleasant flavor with the high nutritional value of specific chemical compounds. However, making rapid measurements of phenolic compounds is a major challenge for the olive oil sector. The development of a new method based on near infrared (NIR) spectroscopy may be considered an important advance for the sector, as it is rapid, low-cost, non-contaminant and non-destructive.

Food inflammation index reveals the key inflammatory components in foods and heterogeneity within food groups: How do we choose food?

Introduction: Food is a critical factor of chronic inflammation. Few studies tried to quantize inflammatory effects of food. Moreover, the discrepancies in inflammatory effects among foods within the same food group are frequently ignored.

Immunochromatographic Strip Based on Tetrahedral DNA Immunoprobe for the Detection of Aflatoxin B in Rice Bran Oil.

Aflatoxin B (AFB), a widespread contaminant in food and feeds, poses a threat to the health of animals and humans. Consequently, it is significant to develop a rapid, precise and highly sensitive analytical method for the detection of AFB. Herein, we developed an immunochromatographic strip (ICS) based on a tetrahedral DNA (TDN) immunoprobe for AFB determination in rice bran oil.

Autophagy-mediated ferroptosis is involved in development of severe acute pancreatitis.

Background: Ferroptosis is a newly recognized form of regulatory cell death characterized by severe lipid peroxidation triggered by iron overload and the production of reactive oxygen species (ROS). However, the role of ferroptosis in severe acute pancreatitis(SAP) has not been fully elucidated.

Methods: We established four severe acute pancreatitis models of rats including the sham control group, the SAP group, the Fer -1-treated SAP (SAP + Fer-1) group, the 3-MA-treated SAP (SAP + 3-MA) group.

Dual-template magnetic molecularly imprinted polymers for selective extraction and sensitive detection of aflatoxin B1 and benzo(α)pyrene in environmental water and edible oil.

The coexistence of multiple contaminates in the environment and food is of growing concern due to their extremely hazard as a well-known class I carcinogen, like aflatoxin B1 (AFB1) and benzo(α)pyrene (BaP). AFB1 and BaP are susceptible to coexistence in environmental water and edible oil, posing a significant potential risk to environmental monitoring and food safety. The remaining challenges in detecting multiple contaminates include unsatisfied sensitivity, insufficient targets selectivity, and interferences in complex matrices.

Bioinformatics analysis of potential common pathogenic mechanisms for COVID-19 and venous thromboembolism.

Background: A growing body of research has shown that patients with coronavirus disease 2019 (COVID-19) have significantly higher rates of venous thromboembolism (VTE) than healthy. However, the mechanism remains incompletely elucidated. This study aimed to further investigate the molecular mechanisms underlying the development of this complication.

Moderate elimination of mycotoxins in vegetable oil triggered by superoxide anion and singlet oxygen.

Establishing a moderate elimination strategy for mycotoxins with the maintained food nutrition is significant to food safety. Herein, the Au-NPs decorated defective BiWO (Au-BWO-OV) with modulated ROS generation was successfully synthesized, integrating the merits of defect-engineering and Au-NPs induced LSPR-effect. The Au-BWO-OV exhibited modified photoelectrochemical property and O-adsorption capacity, supporting the selective generation of •O and O with moderate oxidizing ability.

Optimization of QuEChERS cleanup for quantification of γ-oryzanol in vegetable oils by UHPLC-MS/MS.

This study was based on QuEChERS cleanup coupled with UHPLC-MS/MS for the determination of γ-oryzanol compounds in vegetable oils. Several parameters of QuEChERS and UHPLC-MS/MS were studied for purification and detection of γ-oryzanol compounds in oil samples. Under the optimized conditions, the whole pretreatment procedure could be accomplished within 10 min without tedious procedure, larger volume of organic solvent and complicated apparatus.

Nutrients in rice bran oil and their nutritional functions: a review.

Rice is an important food crop throughout the world. Rice bran, the outer layer of rice grain, is a by-product generated during the rice milling process. Rice bran oil (RBO) is extracted from rice bran and has also become increasingly popular.

GSDMD in regulated cell death: A novel therapeutic target for sepsis.

Sepsis is a life-threatening multi-organ dysfunction syndrome caused by an abnormal host response to infection. Regulated cell death is essential for maintaining tissue homeostasis and eliminating damaged, infected, or aging cells in multicellular organisms. Gasdermin D, as a member of the gasdermin family, plays a crucial role in the formation of cytoplasmic membrane pores.

MOF-derived nanozyme CuOx@C and its application for cascade colorimetric detection of phytosterols.

Phytosterols (PSs), a class of naturally occurring bioactive lipid compounds, have been found to possess a significant cholesterol-lowering effect. In developing countries, the consumption of rapeseed oil is the primary pathway of PS intake for the general population. However, developing low-cost, real-time, and high-throughput screening techniques for PSs remains a challenge.