Synopsis of recent research by authors named "Peisheng Hu"
- Peisheng Hu's research primarily focuses on the development and optimization of chimeric antigen receptor (CAR) T-cell therapies and the utilization of antibody-based therapeutics for cancer and neurological diseases, leveraging techniques like PET imaging for biodistribution assessment and glycosylation variations for pharmacokinetic insights.
- Notable findings include the identification of an improved Lym-1 CAR T-cell design demonstrating increased antitumor activity in B-cell lymphoma models, and the successful application of Zr-oxine PET imaging for real-time monitoring of CAR T-cell distribution in preclinical tumor models.
- Additionally, Hu's work addresses challenges such as the blood-brain barrier in delivering therapeutic antibodies to the central nervous system, highlighting the significance of effective drug delivery and immune modulation in treating complex diseases like type 2 diabetes and cancer.
