Mechanisms of action and adaptive responses to diclofenac and meloxicam during the early life stages of Oryzias melastigma.

Non-steroidal anti-inflammatory drugs (NSAIDs), though designed to target specific molecular pathways, pose significant environmental risks to non-target organisms, particularly marine fish. This study investigated the toxicity mechanisms and adaptive responses to diclofenac (DCF) and meloxicam (MEX) during the early life stages (ELS) of Oryzias melastigma at environmentally relevant concentrations over a 31-day period. Mechanistic investigations of sub-lethal effects were conducted using Enzyme-Linked Immunosorbent Assay (ELISA), RNA sequencing (RNA-Seq) and quantitative PCR (qPCR).

Needling Neiguan (P 6) for treatment of low pulse pressure syndrome--a report of 31 cases.

Objective: To observe the impact of needling Neiguan (P 6) on the cardiovascular functional status in low pulse pressure syndrome.

Method: 49 eligible patients were randomly assigned to a acupuncture group with bilateral Neiguan (P 6) needled for successive 3 days, and a medication group given a daily 20 mL of Shenmai Injectio intravenously dripped for successive 6 days. The blood pressure, pulse pressure, stroke volume (SV), cardiac output(CO)/min, left ventricle work index (LVWI), mean arterial pressure (MAP), total peripheral resistance (TPR), coronary perfusion pressure (CPP), pulmonary arterial wedge pressure (PAWP), effective blood volume (BV), blood viscosity (N), microcirculation half renewal rate (MHR), and cardiac muscle blood volume (CMBV) were determined before and after the treatment, which were compared with the parameters obtained in 23 healthy subjects.