Deep learning algorithm performance in contouring head and neck organs at risk: a systematic review and single-arm meta-analysis.

Purpose: The contouring of organs at risk (OARs) in head and neck cancer radiation treatment planning is a crucial, yet repetitive and time-consuming process. Recent studies have applied deep learning (DL) algorithms to automatically contour head and neck OARs. This study aims to conduct a systematic review and meta-analysis to summarize and analyze the performance of DL algorithms in contouring head and neck OARs.

[Impacts of Climate Change and Human Activities on NDVI Change in Eastern Coastal Areas of China].

Based on the datasets of normalized difference vegetation index (NDVI), temperature, precipitation, and solar radiation and the methods of trend, partial correlation, and residual analyses, this study explored the spatiotemporal variation in NDVI and its response to climate change from 1982 to 2019 in eastern coastal areas of China. Then, the effects of climate change and non-climatic factors (e.g.

Genome-wide DNA methylation profiles and small noncoding RNA signatures in sperm with a high DNA fragmentation index.

Background: A growing number of studies have reported that sperm DNA fragmentation (SDF) is associated with male infertility. However, no studies have compared genome-wide DNA methylation profiles and sncRNA signatures between sperm with high and low sperm DNA fragmentation indices (DFIs).

Methods: Whole-genome bisulfite sequencing (WGBS) was performed on sperm samples from a weak group (DFI ≥ 30%, n = 6) and normal group (DFI ≤ 15%, n = 7).

Altered DNA methylation pattern reveals epigenetic regulation of Hox genes in thoracic aortic dissection and serves as a biomarker in disease diagnosis.

Background: Thoracic aortic dissection (TAD) is a severe disease with limited understandings in its pathogenesis. Altered DNA methylation has been revealed to be involved in many diseases etiology. Few studies have examined the role of DNA methylation in the development of TAD.

Matrix hardness regulates the cancer cell malignant progression through cytoskeletal network.

The tumor microenvironment is a complex microenvironment that combines the biochemical and biophysical factors. When the cells are exposed to the microenvironment, the direct biophysical factor is the matrix hardness. As an auxiliary indicator of clinical disease diagnosis, it is still not clear how the matrix hardness induces cell malignant changes and the regulation mechanisms.

Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system.

The architecture and function of chromatin are largely regulated by local interacting molecules, such as transcription factors and noncoding RNAs. However, our understanding of these regulatory molecules at a given locus is limited because of technical difficulties. Here, we describe the use of Clustered Regularly Interspaced Short Palindromic Repeats and an engineered ascorbate peroxidase 2 (APEX2) system to investigate local chromatin interactions (CAPLOCUS).

CELF1 contributes to aberrant alternative splicing patterns in the type 1 diabetic heart.

Dysregulated alternative splicing (AS) that contributes to diabetes pathogenesis has been identified, but little is known about the RNA binding proteins (RBPs) involved. We have previously found that the RBP CELF1 is upregulated in the diabetic heart; however, it is unclear if CELF1 contributes to diabetes-induced AS changes. Utilizing genome wide approaches, we identified extensive changes in AS patterns in Type 1 diabetic (T1D) mouse hearts.

DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene upregulates its expression by inhibition of TFAP2A binding.

Background: Genome-wide association studies (GWASs) have identified dozens of loci associated with gout, but for most cases, the risk genes and the underlying molecular mechanisms contributing to these associations are unknown. This study sought to understand the molecular mechanism of a common genetic variant, rs780093, in the development of gout, both in vitro and in vivo.

Results: Nuclear receptor binding protein 1 (), as a gout risk gene, and its regulatory region, 72 bp upstream of the transcription start site, designated as B1, were identified through integrative analyses of genome-wide genotype and DNA methylation data.

Worrying Thoughts Limit Working Memory Capacity in Math Anxiety.

Sixty-one high-math-anxious persons and sixty-one low-math-anxious persons completed a modified working memory capacity task, designed to measure working memory capacity under a dysfunctional math-related context and working memory capacity under a valence-neutral context. Participants were required to perform simple tasks with emotionally benign material (i.e.

Selective enrichment and desalting of hydrophilic peptides using graphene oxide.

The wide variety and low abundance of peptides in tissue brought great difficulties to the separation and identification of peptides, which is not in favor of the development of peptidomics. RP-HPLC, which could purify small molecules based on their hydrophobicity, has been widely used in the separation and enrichment of peptide due to its fast, good reproducibility and high resolution. However, RP-HPLC requires the instrument and expensive C18 column and its sample capacity is also limited.

An EEG study on the effect of self-relevant possessive pronoun: self-referential content and first-person perspective.

The present study aimed at examining the brain mechanism of the effect of self-relevant possessive pronoun (SRPP). Eighteen participants observed the following stimuli: "wo de" (Chinese for "my"/"mine"), "ta de" (Chinese for "his"), "wo" (Chinese for "I"/"me"), "ta" (Chinese for "he"/"him"), small circle and big circle. Relative to "ta de", "wo" and "ta", "wo de" elicited a significantly larger P300 amplitude, i.

Effects of ownership expressed by the first-person possessive pronoun.

The present study examined the behavioral effects of the first-person possessive pronoun. In each trial, a noun (e.g.

An ERP study on the effect of self-relevant possessive pronoun.

The present study examined the electrophysiological correlates of the psychological processing of possessive pronouns such as "wo de" (Chinese for "my"/"mine") and "ta de" (Chinese for "his") using a three-stimulus oddball paradigm. Sixteen participants were visually presented the stimuli (possessive pronouns, small circle and big circle). The results showed that, relative to non-self-relevant possessive pronoun "ta de", self-relevant possessive pronoun "wo de" elicited a significantly larger P300 amplitude independently.