Heterogeneity evaluation of multi-high -value apparent diffusion coefficient on cerebral ischemia in MCAO rat.

Purpose: To assess brain damage in a rat model of cerebral ischemia based on apparent diffusion coefficient (ADC) data obtained from multi-high -values and evaluate the relationship between Aquaporin 4 (AQP4) expression and ADC.

Methods: Thirty eight male Sprague-Dawley rats were randomized into two groups: (1) sham controls ( = 6) and (2) cerebral ischemia (successful model, = 19). All rats underwent diffusion-weighted imaging (DWI) with both standard -values and multi-high -values (2,500-4,500 s/mm) using a 3.