Efficacy and Safety of Hepatic Arterial Infusion Therapy with Cinobufacini in Advanced Hepatocellular Carcinoma with Macrovascular Invasion: A Retrospective Cohort Study.

Background: The presence of macrovascular invasion (MVI) is associated with poor prognosis in advanced hepatocellular carcinoma (HCC). This study aims to evaluate the efficacy and safety of Cinobufacini therapy via hepatic arterial infusion (HAI) in advanced HCC patients with MVI.

Methods: The clinical records of 130 consecutive patients with unresectable advanced HCC and MVI who had received Cinobufacini or cisplatin plus 5-fluorouracil (CF) treatment via HAI were retrospectively analyzed.

Efficacy of denosumab on bone metabolism and bone mineral density in renal transplant recipients: A systematic review and meta-analysis.

Background: Post-transplant bone disease (PTBD) is a common complication in kidney transplant recipients. This systematic review and meta-analysis evaluates the efficiency and safety of denosumab for the treatment of PTBD in kidney transplant recipients.

Methods: Comprehensive search of PubMed Central, SCOPUS, EMBASE, MEDLINE, Cochrane trial registry, Google Scholar, and Clinicaltrials.

[Meta-analysis of energetic nutritional intervention for stable chronic obstructive pulmonary disease patients].

Objective: To conduct a meta-analysis of randomized controlled trials (RCTs) to clarify whether nutritional intervention (caloric supplementation for at least 2 weeks) can improve the nutritional status and the pulmonary functions, while reduce the frequency of acute exacerbation or mortality of patients with stable COPD.

Methods: RCTs were identified from databases including Medline and Embase, and a hand search for references was also conducted. Two reviewers independently selected the trials for inclusion, assessed the methodological quality of each study, and extracted the data Within each trial and for each outcome, an effect size was calculated.