The Effects of Pb on TNF-R1-RIPK1/RIPK3 Signaling Pathway in the Hippocampus of Mice.

Lead (Pb), a dense, soft, blue-gray metal, is widely used in metallurgy, cables, storage batteries, pigments, and other industrial applications. Pb has been shown to cause degenerative changes in the nervous system. Necroptosis, a form of non-apoptotic programmed cell death modality, is closely associated with neurodegenerative diseases.

Inflammation in Metal-Induced Neurological Disorders and Neurodegenerative Diseases.

Essential metals play critical roles in maintaining human health as they participate in various physiological activities. Nonetheless, both excessive accumulation and deficiency of these metals may result in neurotoxicity secondary to neuroinflammation and the activation of microglia and astrocytes. Activation of these cells can promote the release of pro-inflammatory cytokines.

Flexible capacitive pressure sensor with sensitivity and linear measuring range enhanced based on porous composite of carbon conductive paste and polydimethylsiloxane.

In recent years, the development of electronic skin and smart wearable body sensors has put forward high requirements for flexible pressure sensors with high sensitivity and large linear measuring range. However, it turns out to be difficult to increase both of them simultaneously. In this paper, a flexible capacitive pressure sensor based on a porous carbon conductive paste-polydimethylsiloxane composite is reported, the sensitivity and the linear measuring range of which were developed using multiple methods including adjusting the stiffness of the dielectric layer material, fabricating a microstructure and increasing the dielectric permittivity of the dielectric layer.