Publications by authors named "Peimin Huang"
Article Synopsis
- Transthyretin Amyloidosis is caused by the misfolding of the transthyretin protein, and this study explores how guanine-rich regions in its gene can form G-quadruplex structures, which may affect gene transcription.
- Small molecule ligands like TMPyP4 and Braco-19 were shown to stabilize these G-quadruplexes, particularly enhancing the stability of one sequence identified as Ttrg 3.
- The study found that treating HepG2 cells with these ligands significantly reduced transthyretin mRNA levels without causing cell death, suggesting G-quadruplex stabilization could be a new therapeutic strategy for treating Transthyretin Amyloidosis.
The aim of this study is to see if the centre of pressure (COP) measurements on the postural stability can be used to represent the electromyography (EMG) measurement on the activity data of lower limb muscles. If so, the cost-effective COP data measurements can be used to indicate the level of postural stability and lower limb muscle activity. The Hilbert-Huang Transform method was used to analyse the data from the experimental designed to examine the correlation between lower-limb muscles and postural stability.
View Article and Find Full Text PDFWe report a facile and versatile method for fabrication of multiheteroatom-doped hierarchically porous carbon with a large specific surface area, using the 3D network constructed by ZIF-8 coated wormlike micelles as template. The uniform and highly pure wormlike micelles developed in our laboratory is essential, because they not only are responsible for the formation of hierarchical porosity, but also play as a versatile platform for multiheteroatoms doping. In a primary experiment, S, N, B, and P heteroatoms were doped conveniently and the resultant porous carbons have the excellent oxygen reduction reaction performance comparable to the commercial 20% Pt/C.
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