Publications by authors named "Peilin Zou"
Background: Malnutrition is a complication of chronic kidney disease (CKD). Whether malnutrition, assessed via the geriatric nutritional risk index (GNRI), is associated with the incidence and risk of CKD in older individuals remains unclear.
Methods: Data from the National Health and Nutrition Examination Survey and the UK Biobank database were used.
Background: The efficacy of surgical treatment for benign prostatic hyperplasia (BPH) patients with detrusor underactivity (DU) remains controversial.
Methods: To summarize relevant evidence, three databases (PubMed, Embase, and Web of Science) were searched from database inception to May 1, 2023. Transurethral surgical treatment modalities include transurethral prostatectomy (TURP), photoselective vaporization of the prostate (PVP), and transurethral incision of the prostate (TUIP).
Background: Heart failure (HF) is one of the major causes of mortality worldwide with high recurrence rate and poor prognosis. Our study aimed to investigate potential mechanisms and drug targets of Shenfu Qiangxin (SFQX), a cardiotonic-diuretic traditional Chinese medicine, in treating HF.
Methods: An HF-related and SFQX-targeted gene set was established using disease-gene databases and the Traditional Chinese Medicine Systems Pharmacology database.
Article Synopsis
- This study examines how tau pathology affects episodic memory loss in Alzheimer's disease (AD), focusing specifically on ventral hippocampal CA1 (vCA1) neurons and their response to tau accumulation.
- Using various methods including proteomic analysis and social behavior tests on mice, the research identifies significant changes in excitatory and parvalbumin neurons in vCA1 associated with AD-like conditions.
- The findings suggest that activating these neurons can improve social memory impaired by tau, and that administering ursolic acid may reduce tau accumulation and restore neuron function, highlighting potential therapeutic approaches for AD-related memory loss.