Distinct strategies of microeukaryotic generalists and specialists in Qinghai-Tibet plateau sediment driven by salinity.

Unraveling how microeukaryotic generalists and specialists assemble and coexist under environmental stress is central to our understanding of the mechanisms maintaining diversity. Here, we explored the biogeographical distributions of microeukaryotic generalists and specialists in lake surface sediments along a salinity gradient on the Qinghai-Tibet Plateau. We found that relative abundances of Chlorophyta (28.

Strong associations between dissolved organic matter and microbial communities in the sediments of Qinghai-Tibetan Plateau lakes depend on salinity.

In aquatic ecosystems, dissolved organic matter (DOM) plays a vital role in microbial communities and the biogeochemical cycling of elements. However, little is known about the associations between DOM and microbial communities in lake sediments. This study investigated the composition of water-extractable organic matter and microbial communities in surface sediments of lakes with different salinities on the Qinghai-Tibet Plateau.

sp. nov., a new pathogen isolated from a patient with primary cutaneous nocardiosis.

A novel nocardioform strain, CICC 11023, was isolated from a tissue biopsy of neck lesions of a patient with primary cutaneous nocardiosis and characterized to establish its taxonomic position. The morphological, biochemical, physiological and chemotaxonomic properties of strain CICC 11023 were consistent with classification in the genus . Whole-cell hydrolysates were rich in meso-diaminopimelic acid, galactose, arabinose and fructose.

ZEB1 Promotes Chemoresistance to Cisplatin in Ovarian Cancer Cells by Suppressing SLC3A2.

Ovarian cancer is one of the deadliest gynecological malignancies in women. Chemoresistance has been a major obstacle for ovarian cancer treatment. Zinc finger E-box-binding homeobox 1 (ZEB1) is an important regulator of tumor development in various types of cancer.

miR-199a-3p enhances cisplatin sensitivity of ovarian cancer cells by targeting ITGB8.

Drug resistance remains a large obstacle for the treatment of ovarian cancer. miRNAs have been reported to be involved in cisplatin (CDDP) resistance in ovarian cancer. The aim of the present study was to investigate the function and mechanism of miR-199a-3p in the CDDP resistance in ovarian cancer.

A randomised double-blind, placebo-controlled trial of allogeneic umbilical cord-derived mesenchymal stem cell for lupus nephritis.

Objective: We evaluate the efficacy of human umbilical cord-derived mesenchymal stem cell (hUC-MSC) for the treatment of lupus nephritis (LN). Previous reports showed hUC-MSC could have dramatic treatment effect.

Methods: Eighteen patients with WHO class III or IV LN were randomly assigned to hUC-MSC (dose 2×10 cells) or placebo.

Cryptococcal meningitis in systemic lupus erythematosus patients: pooled analysis and systematic review.

Cryptococcal meningitis is an important fungal infection among systemic lupus erythematosus patients. We conducted a pooled analysis and systematic review to describe the epidemiological and clinical profile of cryptococcal meningitis in systemic lupus erythematosus patients. From two hospitals in China and nine literature databases, cases and prevalence data were collected for pooled analysis and meta-analysis, respectively.

miR-146a Inhibits Proliferation and Enhances Chemosensitivity in Epithelial Ovarian Cancer via Reduction of SOD2.

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, accounting for 90% of all ovarian cancer. Dysregulation of miRNAs is associated with several types of EOC. In the current research, we aimed to study the role of abnormal expression of miR-146a in the development of EOC and to elucidate the possible molecular mechanisms.

[A study on the relationship between insulin-like growth factor, insulin-like growth factor-binding protein-3 and fetal growth retardation].

Objective: To explore the effect of insulin-like growth factor-I (IGF-I), insulin-like growth factor-II (IGF-II) and insulin-like growth factor-binding protein-3 (IGFBP-3) on the fetal growth.

Methods: Samples of maternal blood and matched umbilical cord blood were collected at time of delivery from twenty pairs of mothers and newborns with normal birth weight (control group) twenty pairs with fetal growth restriction (FGR group) and ten pairs with macrosomia (macrosomia group). Serum IGF-I, IGF-II and IGFBP-3 were measured by radioimmunoassay (RIA) and immunoradiometric analysis (IRMA).