Glycosparvine A, a new indole alkaloid from the leaves of .

In the course of our ongoing search for biologically active compounds from medicinal plant, the ethyl acetate extract from the leaves of (Rutaceae) was investigated. Six compounds including a new indole alkaloid, glycosparvine A (), and five previously known metabolites (-) were identified. The structure of the new compound () was unambiguously elucidated by spectroscopic analyses, including 1D/2D NMR spectroscopy and HRESIMS.

Cuparene-type sesquiterpenes with neuroprotective activities from the edible mushroom Flammulina filiformis.

Four new cuparene-type sesquiterpenes, flammuterpenols A - D (1-4), along with one known congener (5) were isolated from the solid culture of edible mushroom Flammulina filiformis. Their structures with a benzoxabicyclo[3.2.

A near-infrared ratiometric fluorescent probe for the sensing and imaging of sulfur dioxide derivatives in living systems.

As a reactive sulfur species, sulfur dioxide (SO) and its derivatives play crucial role in various physiological processes, which can maintain redox homeostasis at normal levels and lead to the occurrence of many diseases at abnormal levels. So, the development of a suitable fluorescent probe is a crucial step in advancing our understanding of the role of SO derivatives in living organisms. Herein, we developed a near-infrared fluorescent probe (SP) based on the ICT mechanism to monitor SO derivatives in living organisms in a ratiometric manner.

Bioactive sulfur-containing amides from the leaves of .

Two new sulphur-containing amides, glylucidamides C-D (-), along with twelve known analogues (-) were isolated and characterised from the leaves of . The chemical structures of and were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literatures. All new compounds were evaluated for their anti-inflammatory activities examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.

Tumor-overexpressed enzyme responsive amphiphiles small molecular self-assembly nano-prodrug for the chemo-phototherapy against non-small-cell lung cancer.

Rational design of self-assembly drug amphiphiles can provide a promising strategy for constructing nano-prodrug with high drug loading, smart stimuli-responsive drug release and high tumor selectivity. Herein, we report a small molecular amphiphile prodrug that can self-assemble into multifunctional nano-prodrug for enhanced anticancer effect by the combination of chemotherapy and phototherapy (PDT/PTT). In this prodrug, the simple insertion of quinone propionate into hydrophilic drug Irinotecan (Ir) generates suitable amphiphiles that endow a good self-assembly behavior of the prodrug and transform it into a stable and uniform nanoparticle.

A self-assembly nano-prodrug for triple-negative breast cancer combined treatment by ferroptosis therapy and chemotherapy.

Chemotherapeutics have been recommended as the standard protocol for inoperable patients with triple-negative breast cancer (TNBC) at advanced stage, yet limited success has been achieved in prolonging survival rates by this monotherapy. A major reason for this failure is the chemo-resistance from traditional apoptotic pathways resulting in poor therapeutic effect. Ferroptosis has become a powerful modality of no-apoptotic cell death, which can effectively evade chemo-resistance in apoptotic pathways.

A novel dual-channel fluorescent probe for selectively and sensitively imaging endogenous nitric oxide in living cells and zebrafish.

Nitric oxide (NO) plays various physiological and pathological roles in lots of biological processes. It is crucial to detect NO sensitively and selectively in vivo and in vitro as homeostasis of NO is closely related to various diseases. Herein, a novel dual-channel fluorescent dye (ENNH) based on dicarboxyimide anthracene was developed as a highly sensitive and selective probe to detect NO in living systems using the dual-channel fluorescence.

A biomimetic nanodrug self-assembled from small molecules for enhanced ferroptosis therapy.

Ferroptosis drugs often induce oxidative damage or block antioxidant defense due to the key mechanism of ferroptosis involved in cancer treatment, regulating the intracellular redox balance. However, these ferroptosis drugs are unstable during systemic circulation, and they lack tumor-targeting capability. Herein, we developed a stimuli-responsive and cell membrane-coated nanodrug for the simultaneous delivery of two ferroptosis drugs, an iron-chelating drug as a ROS inducer and sorafenib as an antioxidase inhibitor.

A metal-organic framework/aptamer system as a fluorescent biosensor for determination of aflatoxin B1 in food samples.

The demand of simple, sensitive, selective and reliable assay for aflatoxin B1 (AFB1) detection is ubiquitous in food safety, due to its high toxic. Herein, a novel fluorescent aptasensor using metal-organic frameworks (UiO-66-NH) and TAMRA label aptamer as sensing platform for AFB1 detection was developed. The TAMRA aptamer adsorbed on the surface of UiO-66-NH via van der Waals force and its fluorescence was quenched for the charge transfer from fluorescence dye TAMRA to metal ions of UiO-66-NH.

Nitrogen-sulfur co-doped pH-insensitive fluorescent carbon dots for high sensitive and selective hypochlorite detection.

Carbon dots (CDs) are novel fluorescent carbon nanomaterial with exceptional properties and have drawn great attention in recent years. However, the preparation and applications of high-quality carbon dots remain challenging. Here, we describe a simple hydrothermal synthesis route using citric acid as a carbon source for stable fluorescent CDs.

Synthesis of the cationic fluorescent probes for the detection of anionic surfactants by electrostatic self-assembly.

Anionic surfactants were widespread used in car cleaning agents, household detergents, agricultural and industrial processes, and considered as a major source of environmental pollutant. Therefore, it is necessary to develop a fast, simple, highly selective and sensitive probe for the detection of anionic surfactants. Here, we synthesized two aggregation induced emission (AIE)-active molecules 4,4',4″,4‴-(ethene-1,1,2,2-tetrayltetrakis(benzene-4,1-diyl))tetrakis (1-(4-bromobenzyl)pyridin-1-ium) bromide (TPE-Br) and 4,4',4″,4‴-(ethene-1,1,2,2-trayltetrakis(benzene-4,1-diyl))tetrakis(1-methylpyridin-1-ium)iodide (TPE-I), which were then applied as fluorescence probes for detecting sodium dodecyl sulfate (SDS) with high selectivity and sensitivity.

One Step Preparation of Peptide-Coated Gold Nanoparticles with Tunable Size.

Gold nanoparticles (AuNPs) made from self-assembling peptides have been used in many research fields and attracted a great deal of attention due to their high stability, biocompatibility and functionality. However, existing preparation methods for peptide-coated AuNPs are post-synthesis processes, which are complicated and time consuming. Therefore, a one-step preparation method for peptide-coated AuNPs is proposed here.

1,6-Elimination reaction induced detection of fluoride ions in vitro and in vivo based on a NIR fluorescent probe.

Near-Infrared "turn on" type fluorescent probes are attractive and promising in the fields of chemical sensing and bioimaging. Here, a new dicyanomethylene-4H-pyran derivative (DCM-Si) NIR fluorescent probe was designed and synthesized for specific lighting up F in living cells and bodies. SiO bond was used as F trigger, and the release of fluorophore (DCM-NH) occurred after substituent reaction and subsequent 1,6-elimination.

A label-free fluorescent aptasensor for the detection of Aflatoxin B1 in food samples using AIEgens and graphene oxide.

The detection of Aflatoxin B1 (AFB1) has attracted extensive attention for food safety is a worldwide public health problem. Herein, a novel, simple and label-free fluorescent aptasensor, based on quaternized tetraphenylethene salt (TPE-Z), graphene oxide (GO) and AFB1 aptamer, has been constructed to detect AFB1. In the presence of AFB1, AFB1 aptamer undergoes a conformational switch from single stranded structure to the AFB1/AFB1 aptamer complex upon target binding, which induces the release of TPE-Z/AFB1 aptamer from the surface of GO.

A two-photon-activated prodrug for therapy and drug release monitoring.

A light-activated cleavage strategy for the concomitant release of active drugs and generation of fluorescence changes is highly desirable. Herein a molecular prodrug featuring real-time monitoring of drug localization and release by manipulating fluorophores has been created by constructing a cleavable structure which comprises a photoremovable coumarinyl, an anticancer drug camptothecin, a cleavable linker and a near infrared fluorescent dye dicyanomethylene-4H-pyran (DCM). The fluorescence of coumarinyl and CPT is completely quenched by the DCM moiety via fluorescence resonance energy transfer (FRET).

A self-immolative prodrug nanosystem capable of releasing a drug and a NIR reporter for in vivo imaging and therapy.

In vivo monitoring of the biodistribution and activation of prodrugs is highly attractive, and the self-immolative dendritic architecture is deemed as a promising approach for constructing theranostic prodrug in which the release/activation of different payloads is needed. Herein, A GSH-triggered and self-immolative dendritic platform comprising an anticancer drug camptothecin (CPT), a cleavable linker and a two-photon NIR fluorophore (dicyanomethylene-4H-pyran, DCM) has been developed for in situ tracking of drug release and antitumour therapy. In vitro experiments demonstrate that, the presence of glutathione (GSH) induces the cleavage of the self-immolative linker, resulting in comitant release of the drug and the dye.

A bioorthogonal nanosystem for imaging and in vivo tumor inhibition.

Bioorthogonal bond-cleavage reactions have emerged as promising tools for manipulating biological processes, still the therapeutic effect of these reactions in vivo needs to be explored. Herein a bioorthogonal-activated prodrug has been developed for bioimaging and therapy, which is composed of a Pd-mediated cleavable propargyl, a coumarin fluorophore and a potent anticancer drug. In vitro investigations show that, the presence of a Pd complex induces the cleavage of propargyl and subsequently trigger the cascade of reactions, thereby activating the coumarin fluorophore for imaging and releasing the anticancer drug for therapy.

A self-immolative and DT-diaphorase-activatable prodrug for drug-release tracking and therapy.

DT-diaphorase, which catalyzes the reduction of various biological substances like quinones, is overexpressed in some malignant tumors. However, exploiting this attractive property for the controlled release of an active drug from a prodrug is yet to be fully taken advantage of. Herein we report a DT-diaphorase-based prodrug for concomitant drug-release imaging and cancer chemotherapy.

A DT-diaphorase responsive theranostic prodrug for diagnosis, drug release monitoring and therapy.

A DT-diaphorase-activatable theranostic prodrug, which contains camptothecin, a self-immolative linker and a trigger group, has been developed for the detection of DT-diaphorase, tracking of drug release and selectively killing cancer cells over-expressed with DT-diaphorase. This strategy may offer a new approach for the development of enzyme-catalyzed theranostic anticancer therapeutics.

Poly[[tetra-aqua-μ(4)-fumarato-di-μ(3)-fumarato-dineodymium(III)] trihydrate].

The title coordination polymer, {[Nd(2)(C(4)H(2)O(4))(3)(H(2)O)(4)]·3H(2)O}, was synthesized by the reaction of neodymium(III) nitrate hexa-hydrate with fumaric acid in a water-methanol (7:3) solution. The asymmetric unit comprises two Nd(3+) cations, three fumarate dianions (L(2-)), four aqua ligands and three uncoordinated water mol-ecules. The carboxyl-ate groups of the fumarate dianions exhibit different coordination modes.

3,3,4,4-Tetra-fluoro-1-[2-(3,3,4,4-tetra-fluoro-pyrrolidin-1-yl)phen-yl]pyrrolidine.

The asymmetric unit of the title compound, C(14)H(12)F(8)N(2), contains one tetra-fluoro-pyrrolidine system and one half-mol-ecule of benzene; the latter, together with a second heterocyclic unit, are completed by symmetry, with a twofold crystallographic axis crossing through both the middle of the bond between the C atoms bearing the heterocyclic rings and the opposite C-C bonds of the whole benzene mol-ecule. The pyrrolidine ring shows an envelope conformation with the apex at the N atom. The dihedral angle between the least-squares plane of this ring and the benzene ring is 36.

2-(3,3,4,4-Tetra-fluoro-pyrrolidin-1-yl)aniline.

In the title fluorinated pyrrolidine derivative, C(10)H(10)F(4)N(2), the dihedral angle between the best planes of the benzene and pyrrolidine rings is 62.6 (1)°. The crystal packing features inter-molecular N-H⋯F hydrogen bonds.

Poly[diaquabis-(μ(4)-fumarato-κO:O:O:O)(μ(4)-fumarato-κO:O,O:O:O,O)(μ(2)-fumaric acid-κO:O)dipraseodymium(III)].

The title complex, [Pr(2)(C(4)H(2)O(4))(3)(C(4)H(4)O(4))(H(2)O)(2)](n), was synthesized by reaction of praseodymium(III) nitrate hexa-hydrate with fumaric acid in a water-ethanol (4:1) solution. The asymmetric unit comprises a Pr(3+) cation, one and a half fumarate dianions (L(2-)), one half-mol-ecule of fumaric acid (H(2)L) and one coordinated water mol-ecule. The carboxyl-ate groups of the fumarate dianion and fumaric acid exhibit different coordination modes.