Exploring the Complexity and Promise of Tumor Immunotherapy in Drug Development.

Cancer represents a significant threat to human health, and traditional chemotherapy or cytotoxic therapy is no longer the sole or preferred approach for managing malignant tumors. With advanced research into the immunogenicity of tumor cells and the growing elderly population, tumor immunotherapy has emerged as a prominent therapeutic option. Its significance in treating elderly cancer patients is increasingly recognized.

The anti-cholestatic effects of Franch. alone and combined with (A. Jussieu) T. G. Hartley: dual effects on fecal metabolism and microbial diversity.

Drug dosages and combinations are the main factors that affect the efficacy of pleiotropic traditional Chinese medicine (TCM). Franch. (CF) is a representative TCM with multiple effects and is often combined with (A.

Gradient Pores Enhance Charge Storage Density of Carbonaceous Cathodes for Zn-Ion Capacitor.

Engineering carbonaceous cathode materials with adequately accessible active sites is crucial for unleashing their charge storage potential. Herein, activated meso-microporous shell carbon (MMSC-A) nanofibers are constructed to enhance the zinc ion storage density by forming a gradient-pore structure. A dominating pore size of 0.

Therapeutic potential and pharmacological significance of extracellular vesicles derived from traditional medicinal plants.

Medicinal plants are the primary sources for the discovery of novel medicines and the basis of ethnopharmacological research. While existing studies mainly focus on the chemical compounds, there is little research about the functions of other contents in medicinal plants. Extracellular vesicles (EVs) are functionally active, nanoscale, membrane-bound vesicles secreted by almost all eukaryotic cells.

The zhuyu pill relieves rat cholestasis by regulating the mRNA expression of lipid and bile metabolism associated genes.

The Zhuyu pill (ZYP), composed of Franch. and (A. Jussieu) T.

TMT-based proteomics analysis identifies the interventional mechanisms of Qijia Rougan decoction in improving hepatic fibrosis.

Ethnopharmacological Relevance: Qijia Rougan decoction (QJ), consisting of eight herbs and two animal drugs, is an effective traditional Chinese medicine with hepatoprotective and antifibrotic effects. However, its underlying action mechanism remains unclear.

Aim Of The Study: To explore the mechanism underlying the treatment of liver fibrosis in rats by QJ.

Cycle-level traffic conflict prediction at signalized intersections with LiDAR data and Bayesian deep learning.

Real-time safety prediction models are vital in proactive road safety management strategies. This study develops models to predict traffic conflicts at signalized intersections at the signal cycle level, using advanced Bayesian deep learning techniques and efficient LiDAR points. The modeling framework contains three phases, which are data preprocessing, base deep learning model development, and Bayesian deep learning model development.

Surmounting Cancer Drug Resistance: New Perspective on RNA-Binding Proteins.

RNA-binding proteins (RBPs), being pivotal elements in both physiological and pathological processes, possess the ability to directly impact RNA, thereby exerting a profound influence on cellular life. Furthermore, the dysregulation of RBPs not only induces alterations in the expression levels of genes associated with cancer but also impairs the occurrence of post-transcriptional regulatory mechanisms. Consequently, these circumstances can give rise to aberrations in cellular processes, ultimately resulting in alterations within the proteome.

An Advanced Molecularly Imprinted Photochemical Sensor Based Carbon Quantum dots for Highly Sensitive Detection of Chloramphenicol in Food.

A facile method which combines the advantages of carbon quantum dots and molecular imprinting technology to design a fluorescence molecular imprinting sensor for the high sensitivity and selective detection of chloramphenicol. The fluorescent molecule imprinted polymers are synthesized by sol-gel polymerization using carbon quantum dots as functional monomers and fluorescent sources, TEOS as crosslinkers, breaking with the traditional understanding of an additional functional monomer. Under optimal experimental, as the concentration of chloramphenicol increases, the fluorescence intensity of the fluorescence molecule imprinting sensor gradually decreases.

Carrier-Free Nanoplatform via Evoking Pyroptosis and Immune Response against Breast Cancer.

Pyroptosis, as a novel mode of cell death, has been proven to have impressive antitumor effects. Dying cells undergoing pyroptosis can elicit antitumor immunity by the release of tumor-associated antigens (TAAs) and damage-associated molecular patterns (DAMPs). Accordingly, developing an effective, stable, and controllable nanoplatform that can promote these two side effects is a promising option for cancer therapy.

Nanoparticle-Based Drug Delivery Systems Targeting Tumor Microenvironment for Cancer Immunotherapy Resistance: Current Advances and Applications.

Cancer immunotherapy has shown impressive anti-tumor activity in patients with advanced and early-stage malignant tumors, thus improving long-term survival. However, current cancer immunotherapy is limited by barriers such as low tumor specificity, poor response rate, and systemic toxicities, which result in the development of primary, adaptive, or acquired resistance. Immunotherapy resistance has complex mechanisms that depend on the interaction between tumor cells and the tumor microenvironment (TME).

Identification of Six Genes as Diagnostic Markers for Colorectal Cancer Detection by Integrating Multiple Expression Profiles.

Background: Many studies have demonstrated the promising utility of DNA methylation and miRNA as biomarkers for colorectal cancer (CRC) early detection. However, mRNA is rarely reported. This study aimed to identify novel fecal-based mRNA signatures.

Fuzheng Xiaozheng prescription exerts anti-hepatocellular carcinoma effects by improving lipid and glucose metabolisms via regulating circRNA-miRNA-mRNA networks.

Background: Hepatocellular carcinoma (HCC) is a major threat to human health due to its high lethality. Our previous studies suggested that Fuzheng Xiaozheng prescription (FZXZP), an effective Chinese medicine, demonstrated significant suppressive effects on HCC. However, its underlying mechanism remains largely unclear.

A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer.

Previously used in anti-fungal therapy, itraconazole has now been shown to be successful in treating advanced breast cancer (NCT00798135). However, its poor solubility still restricts its application in clinical treatment. There is therefore an urgent need for combined methods to enhance the therapeutic effect of itraconazole (IC) in breast cancer treatment.

Temporal analysis of cellphone-use-involved crash injury severities: Calling for preventing cellphone-use-involved distracted driving.

With the popularity of smartphones and the increasing dependence on cellphones, cellphone-use-involved distracted driving has become a global traffic safety concern. Calling, texting, or watching videos while driving could have harmful impacts on driving abilities and increase crash-injury severities. To investigate the temporal stability and the heterogeneity of cellphone-involved crash injury severity determinants, a series of likelihood ratio tests and random parameters logit models with heterogeneity in means and variances are estimated.

Core-Shell MOF-in-MOF Nanopore Bifunctional Host of Electrolyte for High-Performance Solid-State Lithium Batteries.

Solid-state lithium-ion batteries with high safety are the encouraging next-generation rechargeable electrochemical energy storage devices. Yet, low Li conductivity of solid electrolyte and instability of solid-solid interface are the key issues hampering the practicability of the solid electrolyte. In this research, core-shell MOF-in-MOF nanopores UIO-66@67 are proposed as a unique bifunctional host of ionic liquid (IL) to fabricate core-shell ionic liquid-solid electrolyte (CSIL).

Anti-hepatocellular carcinoma efficacy of Fuzheng Xiaozheng prescription and its interventional mechanism studies.

Ethnopharmacological Relevance: Fuzheng Xiaozheng prescription (FZXZP), a traditional Chinese medicine, which was derived from the famous decoction, Sanjiasan, in the book of "Wenyilun" in Ming dynasty. Due to its function of invigorating the circulation of blood in Chinese medicine, it was usually used for treating the liver cirrhosis, hepatocellular carcinoma (HCC), etc. Clinical application found that FZXZP exhibited satisfactory therapeutic effects in HCC treatments.

Influence of built environment and roadway characteristics on the frequency of vehicle crashes caused by driver inattention: A comparison between rural roads and urban roads.

Introduction: With prevalent and increased attention to driver inattention (DI) behavior, this research provides a comprehensive investigation of the influence of built environment and roadway characteristics on the DI-related vehicle crash frequency per year. Specifically, a comparative analysis between DI-related crash frequency in rural road segments and urban road segments is conducted.

Method: Utilizing DI-related crash data collected from North Carolina for the period 2013-2017, three types of models: (1) Poisson/negative binomial (NB) model, (2) Poisson hurdle (HP) model/negative binomial hurdle (HNB) model, and (3) random intercepts Poisson hurdle (RIHP) model/random intercepts negative binomial hurdle (RIHNB) model, are applied to handle excessive zeros and unobserved heterogeneity in the dataset.

Fuzheng Xiaozheng prescription relieves rat hepatocellular carcinoma through improving anti-inflammation capacity and regulating lipid related metabolisms.

Ethnopharmacological Relevance: Fuzheng Xiaozheng prescription (FZXZP) is a traditional Chinese medicine (TCM) that was derived from Sanjiasan, a famous decoction documented in the book of Wenyilun in Ming dynasty. Based on our years' clinic application, FZXZP demonstrated satisfactory therapeutic effects in cirrhosis and hepatocellular carcinoma (HCC) treatments. However, the underlying mechanisms are still largely unknown.

A Durable Ni-Zn Microbattery with Ultrahigh-Rate Capability Enabled by In Situ Reconstructed Nanoporous Nickel with Epitaxial Phase.

Powering device for miniaturized electronics is highly desired with well-maintained capacity and high-rate performance. Though Ni-Zn microbattery can meet the demand to some extent with intrinsic fast kinetic, it still suffers irreversible structure degradation due to the repeated lattice strain. Herein, a stable Ni-Zn microbattery with ultrahigh-rate performance is rationally constructed through in situ electrochemical approaches, including the reconstruction of nanoporous nickel and the introduction of epitaxial Zn(OH) nanophase.

Engineering Mesoporous Structure in Amorphous Carbon Boosts Potassium Storage with High Initial Coulombic Efficiency.

Amorphous carbon shows great potential as an anode material for high-performance potassium-ion batteries; however, its abundant defects or micropores generally capture K ions, thus resulting in high irreversible capacity with low initial Coulombic efficiency (ICE) and limited practical application. Herein, pore engineering via a facile self-etching strategy is applied to achieve mesoporous carbon (meso-C) nanowires with interconnected framework. Abundant and evenly distributed mesopores could provide short K pathways for its rapid diffusion.

Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment.

Cancer is a disease which frequently has a poor prognosis. Although multiple therapeutic strategies have been developed for various cancers, including chemotherapy, radiotherapy, and immunotherapy, resistance to these treatments frequently impedes the clinical outcomes. Besides the active resistance driven by genetic and epigenetic alterations in tumor cells, the tumor microenvironment (TME) has also been reported to be a crucial regulator in tumorigenesis, progression, and resistance.