Clinical characteristics in patients with oculomotor paralysis caused by isolated midbrain infarction.

Introduction: The aim of the study was to investigate the clinical characteristics of isolated oculomotor paralysis (OP) cases caused by pure midbrain infarction (MI) with pupil sparing.

Material And Methods: Patients with pure MI and pontine infarction (PI) at our hospital were included in this study. We compared the blood pressure and lipid levels between the two groups.

NBP Cytoprotective Effects Promoting Neuronal Differentiation in BMSCs by Inhibiting the p65/Hes1 Pathway.

Background: Bone marrow-derived mesenchymal stem cell (BMSC) transplantation has become an effective method for treating neurodegenerative diseases.

Objectives: This study investigated the effect of 3-N-butylphthalide (NBP) on the neuronal differentiation of BMSCs and its potential mechanism.

Methods: In this study, a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed to detect cell proliferation and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) staining was conducted to detect the apoptosis of BMSCs.

IRAK-M deficiency exacerbates dopaminergic neuronal damage in a mouse model of sub-acute Parkinson's disease.

Emerging evidence has proved that inflammatory responses aggravate the pathological progression of Parkinson's disease. This study aimed to identify the role of Interleukin-1 receptor-associated kinase-M (IRAK-M) as an important negative regulator of innate immunity, in the pathological progression of Parkinson's disease. In the present study, a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection was administered to prepare the acute and sub-acute Parkinson's disease mouse models.

The value of next-generation sequencing for the diagnosis of Streptococcus suis meningitis.

Objective: The aim of this study was to investigate the value of next-generation sequencing for the diagnosis of Streptococcus suis meningitis.

Methods: Patients with meningitis in the Department of Neurology of the Hainan General Hospital were recruited and divided into a next-generation sequencing group and a control group. In the next-generation sequencing group, we used the next-generation sequencing method to detect the specific pathogenic bacteria in the patients.

Association of MicroRNAs With Risk of Stroke: A Meta-Analysis.

Objectives: Altered expression of microRNAs (miRNAs) may contribute to disease vulnerability. Studies have reported the involvement of miRNA in the pathophysiology of ischemic stroke.

Methods: We performed a meta-analysis of data from 6 studies that used a panel of miRNAs with altered expressions to diagnose ischemic stroke with the Bayesian framework.

Constituents of Morus alba var. multicaulis leaf improve lipid metabolism by activating the AMPK signaling pathway in HepG2 cells.

One new compound, 3Z-1-O-β-D-glucopyranosyl-3-hexene-1,5-diol (1), together with 26 known isolates (2-27) were obtained from the leaf of Morus alba var. multicaulis. Among the known compounds, 7, 11, 12, 14, 15, 18, 19, 23, and 24 were firstly obtained from the Morus genus; 2-5, 8, 10, 13, and 20 were firstly isolated from M.

Optical Transmission Properties of SiN Add-Drop Micro-Ring Resonator Induced by a Fabry-Perot Resonance Effect.

To resolve the problem of miscellaneous peaks and improve the accuracy of data processing in micro-ring resonators (MRRs), we propose an optical transmission model based on a Fabry-Perot (F-P) resonance effect in a SiN add-drop MRR-waveguide structure, which is analyzed using a coupled mode theory and stationary interference method. The analysis indicates the experimentally obtained miscellaneous peaks are mainly induced by the multiple reflections between the two end grating couplers, which form a F-P cavity. In addition, an anti-reflection film on the interface of the grating couplers is proposed to reduce the F-P resonance effect.

Bioactive flavonoids and stilbenes from the leaf of Morus alba var. multicaulis.

Twenty-two flavonoids and stilbenes (1-22) were obtained from the leaf of Morus alba var. multicaulis. Among them, morusalbanosides A (1), B (2), and B (3) were new compounds.

Dual Tunable MZIs Stationary-Wave Integrated Fourier Transform Spectrum Detection.

In order to resolve spectral alias due to under sampling in traditional stationary-wave integrated Fourier transform (SWIFT) spectrometers, an all-on-chip waveguide based on dual tunable Mach-Zehnder interferometer (MZI) stationary-wave integrated Fourier transform technology (DTM-SWIFT) is proposed. Several gold nanowires are asymmetrically positioned at two sides of zero optical path difference and scatter the interference fringes information, which can avoid aliasing of spectral signals and help to gain high spectral resolution. A systematic theoretical analysis is carried on in detail, including the optical distribution characteristics based on multi-beam interference, stationary-wave theorem and signal reconstruction method based on the FT technology.

Identification and Structural Analysis of Spirostanol Saponin from by Integrating Silica Gel Column Chromatography and Liquid Chromatography/Mass Spectrometry Analysis.

Roezl (Mojave), a kind of ornamental plant belonging to the genus (Agavaceae), whose extract exhibits important roles in food, beverage, cosmetic and feed additives owing to its rich spirostanol saponins. To provide a comprehensive chemical profiling of the spirostanol saponins in it, this study was performed by using a multi-phase liquid chromatography method combining a reversed phase chromatography T column with a normal phase chromatography silica column for the separation and an ESI-Q-Exactive-Orbitrap MS in positive ion mode as the detector. By comparing the retention time and ion fragments with standards, thirty-one spirostanol saponins were identified.

Correction to: The structure-activity relationship review of the main bioactive constituents of Morus genus plants.

The article The structure-activity relationship review of the main bioactive constituents of Morus genus plants, written by Jiejing Yan, Jingya Ruan, Peijian Huang, Fan Sun, Dandan Zheng, Yi Zhang and Tao Wang was originally published Online First without Open Access.

The structure-activity relationship review of the main bioactive constituents of Morus genus plants.

Morus genus plants are mainly distributed in the temperate to tropical areas over the world and include 17 species and two subspecies. Due to their excellent pharmacological activity, security in food additives and high value in the national economy, Morus genus plants have drawn more and more attention in recent years. In the light of the references published over the last few decades, flavonoids, benzofurans, stilbenes, and Diels-Alder adducts have been reported to be the main bioactive constituents of Morus genus plants.

Anti-inflammatory constituents from Cortex Dictamni.

Eight new compounds named as dictamalkosides A (1), B (2), C (3), dictamphenosides A (4), B (5), C (6), D (7) and E (8), as well as 23 known ones were obtained from the 70% EtOH extract of Cortex Dictamni. Their structures were ascertained based on the spectroscopic evidences. Among the known compounds, 14, 17-23, 25-28, and 31 were isolated from Dictamnus genus for the first time; 16 and 24 were firstly isolated from this plant.

Bioactive constituents obtained from the fruits of Citrus aurantium.

Three new compounds, citrusauranosides A (1), B (2), and C (3), along with 22 known compounds (4-25) were obtained from the 70% ethanol-water extract of the fruits of Citrus aurantium L.. Their structures were identified by spectroscopic methods.

Separation and Bioactive Assay of 25/-Spirostanol Saponin Diastereomers from Roezl (Mojave) Stems.

In order to find a simple, generic, efficient separation method for 25/-spirostanol saponin diastereomers, the liquid chromatographic retention behaviors of C carbonylation and C unsubstituted 25/-spirostanol saponin diastereomers on different stationary phases (C₈, C, C columns) and different mobile phases (MeOH-1% CH₃COOH and CH₃CN-1% CH₃COOH) were investigated. A C column was firstly found to offer the highest efficiency for the separation of this kind of diastereomers than C₈ and C columns. Meanwhile, the analysis results indicated that both CH₃CN-1% CH₃COOH and MeOH-1% CH₃COOH eluate systems were selective for C unsubstituted 25/-spirostanol saponin diastereomers, while MeOH-1% CH₃COOH possessed better selectivity for C carbonylation ones.

Bioactive Constituents from the Aerial Parts of Less.

Four new thiophenes, (3'')-pluthiophenol (), (3'')-pluthiophenol-4''-acetate (), 3''-ethoxy-(3'')-pluthiophenol (), 3''-ethoxy-(3'')-pluthiophenol-4''-acetate (), together with twenty-five known compounds were obtained from the 70% ethanol-water extract of the aerial parts of Less. Their structures were elucidated by spectroscopic methods. Among the known isolates, compounds , , , , , , , , ⁻ were isolated from Asteraceae family firstly, while compounds , , , , , , , , were isolated from genus for the first time.

Eudesmane-Type Sesquiterpene Glycosides from Dictamnus dasycarpus Turcz.

Eudesmane-type sesquiterpenes have been reported to exhibit varieties of biological activities. During the process of investigating this kind of natural product from the root bark of Turcz., 13 eudesmane-type sesquiterpene glycosides including six new isolates, named as dictameudesmnosides A₁ (), A₂ (), B (), C (), D (), and E (), together with seven known ones (-), were obtained.

Spirostane-Type Saponins Obtained from Yucca schidigera.

It is well known that spirostane-type saponins show various bioactivities. In our on-going program of screening these kinds of constituents from natural products, was found to be rich in them, and nine new spirostanol saponins, Yucca spirostanosides A₁ (), A₂ (), B₁ (), B₂ (), B₃ (), C₁ (), C₂ (), C₃ (), and D₁ (), together with five known ones (-) were isolated from the plant. Their structures were elucidated by extensive spectroscopic methods, including 1D and 2D NMR and MS spectra, and comparing with published data.

Optical Fiber Demodulation System with High Performance for Assessing Fretting Damage of Steam Generator Tubes.

In order to access the fretting damage of the steam generator tube (SGT), a fast fiber Fabry-Perot (F-P) non-scanning correlation demodulation system based on a super luminescent light emitting diode (SLED) was performed. By demodulating the light signal coming out from the F-P force sensor, the radial collision force between the SGT and the tube support plate (TSP) was interrogated. For higher demodulation accuracy, the effects of the center wavelength, bandwidth, and spectrum noise of SLED were discussed in detail.

Fiber Fabry-Perot Force Sensor with Small Volume and High Performance for Assessing Fretting Damage of Steam Generator Tubes.

Measuring the radial collision force between the steam generator tube (SGT) and the tube support plate (TSP) is essential to assess the fretting damage of the SGT. In order to measure the radial collision force, a novel miniaturized force sensor based on fiber Fabry-Perot (F-P) was designed, and the principle and characteristics of the sensor were analyzed in detail. Then, the F-P force sensor was successfully fabricated and calibrated, and the overall dimensions of the encapsulated fiber F-P sensor were 17 mm × 5 mm × 3 mm (L × W × H).