Publications by authors named "Peicheng Xin"
Article Synopsis
- The study investigates how Multiple Myeloma (MM) and Osteonecrosis of the Femoral Head (ONFH) are related through bioinformatics tools, focusing on shared mechanisms of disease.
- By analyzing high-throughput data and using techniques like Weighted Gene Co-expression Network Analysis (WGCNA), researchers identified 418 immune-related comorbid genes linked to both conditions, emphasizing biological processes such as protein synthesis.
- The findings highlight common pathogenic genes and immune dynamics, suggesting that genes like RPS19 and RPL35, along with plasma cell behavior, could provide targets for future therapies against these diseases.
Osteoarthritis (OA) and Myelodysplastic syndrome (MDS) are diseases caused by the same immune disorder with unclear etiology and many similarities in clinical manifestations; however, the specific mechanisms between osteoarthritis and myelodysplastic syndrome are unclear. The expression profile microarrays of osteoarthritis and myelodysplastic syndrome were searched in the GEO database, the intersection of their differential genes was taken, Venn diagrams were constructed to find common pathogenic genes, bioinformatics analysis signaling pathway analysis was performed on the obtained genes, and protein-protein interaction networks were constructed to find hub genes in order to establish diagnostic models for each disease and explore the immune infiltration of hub genes. 52 co-pathogenic genes were screened for association with immune regulation, immune response, and inflammation.
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