Publications by authors named "Peibin Ge"
Am J Transl Res
October 2020
Article Synopsis
- The study investigates how cardiac core circadian genes affect the occurrence of ventricular arrhythmias (VAs) in chronic heart failure (CHF), revealing a distinct pattern in their incidence over the day.
- The researchers created a guinea pig model of CHF and found that while the core clock genes remained stable, VAs were more frequent at certain times, peaking at CT3 compared to CT15 after stimulation.
- They concluded that CLOCK-BMAL1 regulates β1-adrenergic receptor (β1-AR) expression, which in turn influences the rhythm of VAs in CHF, highlighting a transcriptional link between circadian biology and heart arrhythmias.
