Superior survival benefits of triple combination immunotherapy compared to standard chemotherapy as second-line treatment for advanced biliary tract cancer: a retrospective analysis.

Background: Advanced biliary tract cancer (BTC) is associated with a poor prognosis and limited options for second-line treatment. The TOPAZ-1 and KEYNOTE-966 trials have demonstrated the benefits of combining immune checkpoint inhibitors (ICIs) with chemotherapy in treating BTC. However, the efficacy of FOLFOX as a second-line therapy is limited, highlighting the need for more effective treatment approaches.

Novel genetic alterations in liver cancer distinguish distinct clinical outcomes and combination immunotherapy responses.

Genomic profiling has revolutionized therapeutic interventions and the clinical management of liver cancer. However, pathogenetic mechanisms, molecular determinants of recurrence, and predictive biomarkers for first-line treatment (anti-PD-(L)1 plus bevacizumab) in liver cancer remain incompletely understood. Targeted next-generation sequencing (tNGS) (a 603-cancer-gene panel) was applied for the genomic profiling of 232 hepatocellular carcinoma (HCC) and 22 intrahepatic cholangiocarcinoma (ICC) patients, among which 47 unresectable/metastatic HCC patients underwent anti-PD-1 plus bevacizumab therapy.

Advanced renal pelvis carcinoma patient with an ERBB2 insertion mutation: a case report.

The prognosis of renal pelvis cancer is poor and therapeutic options are limited, especially for patients with advanced disease. In this report, we present a case of advanced renal pelvis carcinoma in a male patient in his 60s, characterized by an activating mutation in . Clinical evaluation resulted in a pathological diagnosis of renal pelvis carcinoma with liver metastasis.

RNF43 is associated with genomic features and clinical outcome in BRAF mutant colorectal cancer.

Background: Colorectal cancer (CRC) patients with BRAF mutation have very poor prognosis. It is urgent to search for prognostic factors of BRAF mutant CRC. RNF43 is a ENF ubiquitin ligase of Wnt signaling.

Natural gas spot price prediction research under the background of Russia-Ukraine conflict - based on FS-GA-SVR hybrid model.

The ongoing Russia-Ukraine conflict has led to significant upheaval in the worldwide natural gas sector. Accurate natural gas price forecasting, as an essential tool for mitigating market uncertainty, plays a crucial role in commodity trading and regulatory decision-making. This study aims to develop a hybrid forecasting model, the FS-GA-SVR model, which integrates feature selection (FS), genetic algorithm (GA), and support vector regression (SVR) to investigate Henry Hub natural gas price prediction amidst the Russia-Ukraine conflict.

Clinical and biomarker analyses of sintilimab plus gemcitabine and cisplatin as first-line treatment for patients with advanced biliary tract cancer.

The prognosis of biliary tract cancer (BTC) remains unsatisfactory. This single-arm, phase II clinical trial (ChiCTR2000036652) investigated the efficacy, safety, and predictive biomarkers of sintilimab plus gemcitabine and cisplatin as the first-line treatment for patients with advanced BTCs. The primary endpoint was overall survival (OS).

Therapeutic Effect and Prognosis of Biliary Tract Tumor Transformation.

Biliary tract tumor is a common malignant disease in clinical practice. Its incidence rate and mortality rate are high, which seriously endangers the health of the people. At present, gastrointestinal surgery is mainly used to treat patients at home and abroad.

Feasibility of peaking carbon emissions of the power sector in China's eight regions: decomposition, decoupling, and prediction analysis.

Carbon emissions in the power sector are an important part of China's total carbon emissions and have a significant impact on whether China can achieve the 2030 carbon peak target. Based on the three perspectives of decomposition, decoupling, and prediction, this paper studies the feasibility of carbon emission peaks in eight major regional power sectors in China. First, the generalized Divisia index model (GDIM) is used to decompose the carbon emissions of the eight regional power sectors, and the driving factors and their effects on carbon emissions in the power sector of each region are compared.

Interregional carbon compensation cost forecast and priority index calculation based on the theoretical carbon deficit: China as a case.

Interregional carbon compensation is an important part of ecological compensation. An accurate accounting of the interregional carbon compensation cost is the foundation for establishing a carbon compensation mechanism. Corresponding to the actual carbon deficit, this paper advances, for the first time, the concept of the theoretical carbon deficit and, improves the calculation method of the interregional carbon compensation cost based on the theoretical carbon deficit.

Optimization of an amplification protocol for misfolded proteins by using relaxed control.

We investigate an optimal control problem which arises in the optimization of an amplification technique for misfolded proteins. The improvement of this technique may play a role in the detection of prion diseases. The model consists in a linear system of differential equations with a nonlinear control.

Transfection of chimeric anti-CD138 gene enhances natural killer cell activation and killing of multiple myeloma cells.

Reprogramming of NK cells with a chimeric antigen receptor (CAR) proved an effective strategy to increase NK cell reactivity and recognition specificity toward tumor cells. To enhance the cytotoxicity of NK cells against CD138-positive multiple myeloma (MM) cells, we generated genetically modified NK-92MI cells carrying a CAR that consists of an anti-CD138 single-chain variable fragment (scFv) fused to the CD3ζ chain as a signaling moiety. The genetic modification through a lentiviral vector did not affect the intrinsic cytolytic activity of NK-92MI toward human erythroleukemic cell line K562 cells or CD138-negative targets.