Publications by authors named "PeiLi Wu"

Background: Delayed diagnosis of inflammatory bowel disease (IBD) is common, there is still no effective imaging system to distinguish Crohn's Disease (CD) and Ulcerative Colitis (UC) patients.

Methods: This multicenter retrospective study included IBD patients at three centers between January 2012 and May 2022. The intestinal and perianal imaging signs were evaluated.

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As the climate warms, the consequent moistening of the atmosphere increases extreme precipitation. Precipitation variability should also increase, producing larger wet-dry swings, but that is yet to be confirmed observationally. Here we show that precipitation variability has already grown globally (over 75% of land area) over the past century, as a result of accumulated anthropogenic warming.

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Objectives: To achieve automated quantification of visceral adipose tissue (VAT) distribution in CT images and screen out parameters with discriminative value for inflammatory bowel disease (IBD) subtypes.

Methods: This retrospective multicenter study included Crohn's disease (CD) and ulcerative colitis (UC) patients from three institutions between 2012 and 2021, with patients with acute appendicitis as controls. An automatic VAT segmentation algorithm was developed using abdominal CT scans.

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Diminished ovarian reserve (DOR) refers to a decrease in the number and/or quality of oocytes, leading to infertility, poor ovarian response and adverse pregnancy outcomes. Currently, the pathogenesis of DOR is largely unknown, and the efficacy of existing therapeutic methods is limited. Therefore, in-depth exploration of the mechanism underlying DOR is highly important for identifying molecular therapeutic targets for DOR.

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Introduction: Diabetic kidney disease (DKD) has become the leading cause of end-stage kidney disease (ESKD) in most countries. Recently, long noncoding RNA XIST has been found involved in the development of DKD.

Methods: A total of 1184 hospitalized patients with diabetes were included and divided into four groups based on their estimated glomerular filtration rate (eGFR) and urinary albumin to creatinine ratio (UACR): normal control group (nDKD), DKD with normoalbuminuric and reduced eGFR (NA-DKD), DKD with albuminuria but without reduced eGFR (A-DKD), and DKD with albuminuria and reduced eGFR (Mixed), and then their clinical characteristics were analyzed.

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Background: Both low-carbohydrate (LC) and calorie-restricted (CR) diets have been shown to have metabolic benefits. However, the two regimens have yet to be thoroughly compared. We conducted a 12-week randomized trial to compare the effects of these diets separately and in combination on both weight loss and metabolic risk factors in overweight/obese individuals.

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Background: This study aimed to evaluate whether D-dimer can predict the clinical outcomes of patients with unexplained recurrent implantation failure (URIF) during freeze-thaw embryo transfer (FET) cycles.

Methods: Our study was divided into two parts. The first part was a retrospective study that included 433 patients.

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Flash droughts have occurred frequently worldwide, with a rapid onset that challenges drought monitoring and forecasting capabilities. However, there is no consensus on whether flash droughts have become the new normal because slow droughts may also increase. In this study, we show that drought intensification rates have sped up over subseasonal time scales and that there has been a transition toward more flash droughts over 74% of the global regions identified by the Intergovernmental Panel on Climate Change Special Report on Extreme Events during the past 64 years.

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Endometriosis (EMS) is an estrogen-dependent disease. However, little is known about the regulation of estrogen, a potential therapeutic target, in EMS, which remains very poorly managed in the clinic. We hypothesized that microRNAs (miRNAs) can be exploited therapeutically to regulate transcription factor 21 (TCF21) and steroidogenic factor-1 (SF-1) gene expression.

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The accuracy of an a priori geomagnetic reference map is a significant constraint on the geomagnetic matching navigation method. Especially when the aircraft enters an unknown environment, it is impossible to accomplish the navigation task using traditional geomagnetic navigation methods. Therefore, a geomagnetic/INS integrated matching navigation algorithm for long-scale navigation is proposed in this paper, which can perform navigation tasks regardless of whether there is an a priori geomagnetic map.

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Projected changes of future precipitation extremes exhibit substantial uncertainties among climate models, posing grand challenges to climate actions and adaptation planning. Practical methods for narrowing the projection uncertainty remain elusive. Here, using large model ensembles, we show that the uncertainty in projections of future extratropical extreme precipitation is significantly correlated with the model representations of present-day precipitation variability.

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DNA methylation is closely related to the occurrence and development of many diseases, but its role in obesity is still unclear. This study aimed to find the potential differentially methylated genes associated with obesity occurrence and development. By combining methylation and transcriptome analysis, we identified the key genes in adipose tissue affecting the occurrence and development of obesity and revealed the possible molecular mechanisms involved in obesity pathogenesis.

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In Brief: Insufficient trophoblast invasion at the maternal-fetal interface contributes to abortion-prone pregnancy. Our study shows that decreased levels of IGFBP7 in unexplained recurrent spontaneous abortion (URSA) trophoblast cells inhibit MMP2 and Slug expression as well as trophoblast invasion, suggesting that IGFBP7 should be considered a potential therapeutic protein target in URSA.

Abstract: Insufficient trophoblast invasion at the maternal-fetal interface contributes to abortion-prone pregnancy.

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Purpose: Catenin Beta 1 (CTNNB1) is a key regulator of cell proliferation and invasion in endometriosis; however, its upstream factor is not clear. Long noncoding RNAs may participate in endometriosis. The aim of this study was to investigate the mechanism of interaction between LINC02381 and CTNNB1 in endometriosis.

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Article Synopsis
  • - The study assesses the historical erosion rates in the Chinese Loess Plateau from 1901 to 2016, using the Revised Universal Soil Loss Equation and a double mass curve technique to track the influence of land management and climate.
  • - Erosion rates peaked from the 1930s to 1970s due to deforestation and increased farming, but policies for conservation and revegetation led to significant reductions in erosion rates from the 1980s to 2000s, with a 54.3% decrease by the 2000s.
  • - A recent spike in erosion from 2010 to 2016 has been primarily linked to extreme rainfall events, highlighting the need for advanced erosion control strategies in
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Non-alcoholic fatty liver disease (NAFLD) is a serious health threat worldwide. The aim of this study was to comprehensively describe the metabolic and immunologic characteristics of NAFLD, and to explore potential therapeutic drug targets for NAFLD. Six NAFLD datasets were downloaded from the Gene Expression Omnibus (GEO) database, including GSE48452, GSE63067, GSE66676, GSE89632, GSE24807, and GSE37031.

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Article Synopsis
  • Endometriosis is a chronic, estrogen-driven condition characterized by the abnormal growth of ectopic stromal cells (ESCs), making the search for safer treatments essential, with extracellular vesicles (EVs) from umbilical cord mesenchymal stem cells (UC-MSCs) being a potential solution.
  • The study involved culturing UC-MSCs, extracting EVs, and using them to stimulate ESCs to assess changes in cell proliferation, invasion, and specific estrogen-related protein expressions such as SF-1, ERβ, and aromatase.
  • Results indicated that exposure to 120 μg/mL EVs significantly reduced the levels of cyclin D1 and MMP
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To date, much progress has been made in dietary therapy for obese patients. A low-carbohydrate diet (LCD) has reached a revival in its clinical use during the past decade with undefined mechanisms and debatable efficacy. The gut microbiota has been suggested to promote energy harvesting.

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Highly unusual amounts of rainfall were seen in the 2020 summer in many parts of China, Japan, and South Korea. At the intercontinental scale, case studies have attributed this exceptional event to a displacement of the climatological western North Pacific subtropical anticyclone, potentially associated Indian Ocean sea surface temperature patterns and a mid-latitude wave train emanating from the North Atlantic. Using clusters of spatial patterns of sea level pressure, we show that an unprecedented 80% of the 2020 summer days in East Asia were dominated by clusters of surface pressure greater than normal over the South China Sea.

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The hydrological cycle intensifies under global warming with precipitation increases. How the increased precipitation varies temporally at a given location has vital implications for regional climates and ecosystem services. On the basis of ensemble climate model projections under a high-emission scenario, here, we show that approximately two-thirds of land on Earth will face a "wetter and more variable" hydroclimate on daily to multiyear time scales.

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Objectives: Clarifying the expression of breast cancer receptor is the key to clinical treatment for breast cancer. This study aims to explore the correlation between X-ray and clinical characteristics of 4 molecular subtypes and their receptor types of breast cancer.

Methods: A total of 439 breast cancer patients who confirmed by pathology and performed X-ray examination were enrolled.

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Endometriosis is an estrogen-dependent disease. Our previous study demonstrated that elevated levels of transcription factor 21 (TCF21) in endometriotic tissues enhanced steroidogenic factor-1 (SF-1) and estrogen receptor β (ERβ) expression by forming a heterodimer with upstream stimulatory factor 2 (USF2), allowing these TCF21/USF2 complexes to bind to the promoters of SF-1 and ERβ. Furthermore, TCF21 contributed to the increased proliferation of endometriotic stromal cells (ESCs), suggesting that TCF21 may play a vital role in the pathogenesis of endometriosis.

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Polarization-maintaining fibers (PMFs) have always received great attention in fiber optic communication systems and components which are sensitive to polarization. Moreover, they are widely applied for high-accuracy detection and sensing devices, such as fiber gyroscope, electric/magnetic sensors, multi-parameter sensors, and so on. Here, we demonstrated the combination of a fiber Bragg grating (FBG) and Sagnac interference in the same section of a new type of PANDA-structure PMF for the simultaneous measurement of axial strain and temperature.

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