Publications by authors named "Pei-de Dong"
Article Synopsis
- The study examined the clinicopathological features, immunohistochemistry, genotyping, and patient outcomes of gastrointestinal stromal tumor (GIST) patients in Inner Mongolia, China, over a five-year period.
- A total of 804 patients were analyzed, with findings indicating that GIST is most commonly found in the stomach and tends to affect middle-aged and older individuals, showing a predominance of high-risk cases.
- Results showed good long-term survival rates post-surgery, with 96.3% of high-risk patients surviving three years, highlighting the effectiveness of treatment and the need for ongoing monitoring of risk factors.
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Ribosome biogenesis regulatory protein homolog (RRS1) is an essential factor involved in ribosome biogenesis, while its role in CRC remains largely unclear. Here, we found that RRS1 expression was significantly higher in CRC tissues compared with adjacent normal tissues.
View Article and Find Full Text PDFBackground/aims: This study gives insight into the effect of splenectomy in radical surgery for gastric cancer.
Methodology: The study included 631 patients who underwent radical resection for gastric cancer. Of these 631 patients, 105 underwent splenectomy and 526 had splenic preservation.
Clinical investigation of combined Billroth II with Braun anastomosis for patients with gastric cancer.
Hepatogastroenterology
September 2014
Background/aims: This study gives insight into the effect of combined Billroth II with Braun anastomosis for patients with gastric cancer.
Methodology: The clinical data of 720 patients with gastric cancer who underwent surgical treatment in our hospital from 1997 to 2011 were reviewed retrospectively. The results of different operative approaches were analyzed.
Osteopontin knockdown suppresses the growth and angiogenesis of colon cancer cells.
World J Gastroenterol
August 2014
Aim: To investigate the effects of osteopontin (OPN) gene expression knockdown on colon cancer Lovo cells in vitro.
Methods: Four candidate small interfering RNA (siRNA) constructs targeting the OPN gene and a scrambled control sequence (NC-siRNA) were synthesized and inserted into a pGPU6/GFP/Neo expression vector. After confirmation by restriction enzyme digestion and DNA sequencing, the recombinant plasmids were subsequently transfected into a human colon cancer cell line (Lovo) using a liposome transfection method.
[Effect of human colon carcinoma-associated fibroblasts on biological behavior of colon carcinoma Lovo cells].
Zhonghua Wei Chang Wai Ke Za Zhi
August 2013
Objective: To investigate the effects of human colon carcinoma-associated fibroblasts (CAFs) on proliferation, adhesion, migration and invasion of colon carcinoma Lovo cells.
Methods: The co-culture models among colon CAFs, NFs and Lovo cell were established by conditioned medium (CM) of human colon CAFs and colon normal fibroblasts (NFs). Lovo cells in the blank control group was treated with serum-free culture medium.
Probing the hepatic progenitor cell in human hepatocellular carcinoma.
Gastroenterol Res Pract
March 2013
Objective. The intrahepatic stem cells, also known as hepatic progenitor cells (HPCs), are able to differentiate into hepatocytes and bile duct epithelia. By exposure of different injuries and different hepatocarcinogenic regimens, the mature hepatocytes can no longer effectively regenerate; stem cells are involved in the pathogenesis of hepatocellular carcinoma.
View Article and Find Full Text PDFPredictive role of glutathione-S-transferase gene polymorphisms in the survival of gastric cancer cases.
Asian Pac J Cancer Prev
January 2013
Article Synopsis
- The study aimed to examine the link between specific gene polymorphisms (GSTM, GSTT, GSTP) and survival rates in gastric cancer patients in China.
- A total of 317 gastric cancer patients were followed for an average of 34.2 months, with 120 deaths recorded during the study.
- Results indicated that individuals with the GSTT1-null genotype had a significantly higher risk of death, and those with both null-GSTM1 and null-GSTT1 genotypes also showed increased mortality risk from gastric cancer.
[Expression of metabolic enzymes of fluoropyrimidines in primary colorectal cancer and its clinical significance].
Beijing Da Xue Xue Bao Yi Xue Ban
June 2005
Objective: To investigate the expression of metabolic enzymes of fluoropyrimidines in primary colorectal cancer.
Methods: Sixty-one cases of pathological confirmed primary colorectal cancer were collected in Beijing Cancer Hospital from August 2003 to February 2004. The expressions of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and orotate phosphoribosyl transferase (OPRT) were detected in paired tumor tissues and non-cancerous tissues by RT-PCR.