Clivus-involved immunoglobulin G4 related hypertrophic pachymeningitis mimicking meningioma: A case report.

Background: Immunoglobulin G4 related disease (IgG4-RD) is a fibroinflammatory disease with markedly elevated serum IgG4 levels and fibrous tissue proliferation, accompanied by numerous plasma cells. IgG4 related hypertrophic pachymeningitis (IgG4-RHP) is relatively rare and indistinguishable from other phymatoid diseases before the operation. The risk of long-term immunosuppression needs to be balanced with disease activity.

[Advances in Intraoperative Neurophysiological Monitoring Techniques in Transnasal Endoscopic Skull Base Surgery].

Transnasal endoscopic skull base surgery has been increasing in volume in recent years and its indications are constantly expanding. The potential occurrence of intraoperative and postoperative neurovascular complications deserves special attention from neurosurgeons. Multimodal intraoperative neurophysiological monitoring technology allows neurosurgeons to monitor cerebral perfusion and the functional status of the associated cranial nerves in real time, thereby enabling surgeons to make prompt adjustments in surgical procedures and strategies and reduce the risks of postoperative neurological complications in patients.

[The Role of Cancer-associated Fibroblasts in Invasive Behavior of Pituitary Adenoma].

Objective: To determine the role of cancer associated fibroblasts (CAFs) in the invasive behavior of pituitary adenoma.

Methods: Pituitary adenoma tissues were divided into invasive group (IPA) and non-invasive group (nIPA) according to pre-operative MRI and observations during surgery. Those tissues were cultured and CAFs were identified through a smooth muscle actin (α-SMA).

Management of large medial sphenoid wing meningiomas: a series of 178 cases.

Aim: The aim of this study was to evaluate our treatment and outcome in patients with large medial sphenoid wing meningiomas (SWMs).

Material And Methods: Data from 178 patients with large medial SWMs treated was collected and analyzed retrospectively. Most of patients underwent microsurgical resection under electrophysiological monitoring and Doppler probe.

[Isolation and preliminary identification of stem-like cells in pituitary adenoma].

Objective: To isolate and identify the pituitary adenoma stem-like cells from pituitary adenoma tissue.

Methods: Total RNA was prepared with 42 cases of pituitary adenoma tissue samples frozen in liquid nitrogen, the expression of Nestin was detected by RT-PCR. Tumor spheres were cultured in serum-free conditions and the immunefluorescence were used to detect the expression of stem cell markers such as Nestin, Sox2.

[Effects of bromocriptine on the treatment of prolactinomas in male patients and its influences on their sexual function].

Objective: To explore the effect of bromocriptine in the treatment of male patients with prolactinoma and its impacts on their sexual function.

Methods: The clinical data of 29 male patients with prolactinomas treated with Bromocriptine were analysed, International Index of Erectile Function-5 (IIEF-5) was used to assess the sexual function of married patients before and after the treatment of Bromocriptine.

Results: The main clinical symptoms of male patients with prolactinomas were sexual dysfunction, headache and hypopsia, which were released significantly at 6 months after Bromocriptine therapy, with the decrease of serum prolactin (PRL) level (P < 0.

[Pituitary functional recovery and hormone replacement therapy of patients with pituitary adenoma surgery].

Objective: To study the pituitary functional recovery of patients with pituitary adenoma surgery and to identify appropriate dosages of hormone replacement for those patients.

Methods: Serum hormone levels of 187 patients with pituitary adenoma were detected before and after surgery.

Results: The lowest serum hormone levels were detected on the 3rd day after surgery (P < 0.

[Postoperative management of patients with sellar tumors through monitoring urine volume and urine electrolytes].

Objective: To determine the value of urine volume and urine electrolytes in postoperative management of patients with sellar tumors.

Methods: Medical records of 103 patients with sellar tumors in the West China Hospital from January 2009 to December 2009 were retrospectively reviewed. The patients were managed either based on blood electrolytes (Group A, n = 56) or based on urine volume and urine electrolytes (Group B, n = 47).

[Repair and reconstruction of diaphragmatic defect during transcranial pituitary adenoma surgery].

Objective: To investigate the application value of titanium-clip and artificial menigeal in the sella diaphragm repair and reconstruction during transcranial pituitary adenoma surgery.

Methods: Thirty eight patients undergoing transcranial pituitary adenoma surgery received sella diaphragmatic defect repair and reconstruction after the removal of tumor, intraoperative diaphragmatic defect was classified as three grades, titanium-clip, artificial menigeal and EC glue were used for the sella diaphragmatic repair and reconstruction. The short-term and long-term complications were compared with those in the control group which contains 74 patients without diaphragmatic reconstruction.

[Apoptosis and differentiation induced with TCLA in rat glioblastoma cells in vitro].

Objective: To investigate the effect of conjugated trienoic fatty acids on the growth inhibition, apoptosis in rat glioblastoma cells and to elucidate its mechanism of activity.

Methods: Rat glioblastoma cells were tested in vitro cytotoxicity, colony formation inhibition, Brdu incorporation after treatment with TCLA. Its effect of apoptosis induction was detected through Hoechst 33342 staining, cell cycle analysis.