Endogenous corticotropin-releasing factor potentiates the excitability of presympathetic neurons in paraventricular nucleus via activation of its receptor 1 in spontaneously hypertensive rats.

It is well established that increased excitability of the presympathetic neurons in the hypothalamic paraventricular nucleus (PVN) during hypertension leads to heightened sympathetic outflow and hypertension. However, the mechanism underlying the overactivation of PVN presympathetic neurons remains unclear. This study aimed to investigate the role of endogenous corticotropin-releasing factor (CRF) on the excitability of presympathetic neurons in PVN using Western blot, arterial blood pressure (ABP) and renal sympathetic nerve activity (RSNA) recording, CRISPR/Cas9 technique and patch-clamp technique.

Long-Range Nonequilibrium Coherent Tunneling Induced by Fractional Vibronic Resonances.

We study the influence of a linear energy bias on a nonequilibrium excitation on a chain of molecules coupled to local vibrations (a tilted Holstein model) using both a random-walk rate kernel theory and a nonperturbative, massively parallelized adaptive-basis algorithm. We uncover structured and discrete vibronic resonance behavior fundamentally different from both linear response theory and homogeneous polaron dynamics. Remarkably, resonance between the phonon energy ℏω and the bias δ occurs not only at integer but also fractional ratios δ/(ℏω) = /, which effect long-range -bond -phonon tunneling.

Quantum Effects in Chemical Reactions under Polaritonic Vibrational Strong Coupling.

The electromagnetic field in an optical cavity can dramatically modify and even control chemical reactivity via vibrational strong coupling (VSC). Since the typical vibration and cavity frequencies are considerably larger than thermal energy, it is essential to adopt a quantum description of cavity-catalyzed adiabatic chemical reactions. Using quantum transition state theory (TST), we examine the coherent nature of adiabatic reactions in cavities and derive the cavity-induced changes in eigenfrequencies, zero-point energy, and quantum tunneling.

Steady-State Analysis of Light-Harvesting Energy Transfer Driven by Incoherent Light: From Dimers to Networks.

The question of how quantum coherence facilitates energy transfer has been intensively debated in the scientific community. Since natural and artificial light-harvesting units operate under the stationary condition, we address this question via a nonequilibrium steady-state analysis of a molecular dimer irradiated by incoherent sunlight and then generalize the key predictions to arbitrarily complex exciton networks. The central result of the steady-state analysis is the coherence-flux-efficiency relation: η = κ = 2Im[ρ]κ, where is the normalization constant.

Adolescent Perceptions of Peer Responses to Diabetes Self-Management: A Qualitative Study.

Background: Type 1 diabetes (T1D) is more prevalent in adolescents than in adults, and the self-management of insulin-dependent diabetes is complex. T1D requires injections of insulin, self-management of blood testing, regular physical activity, and diet monitoring, which are challenging for growing and developing adolescents. Adolescents are often more concerned with how they are perceived by their peers than how they perceive themselves.

Non-equilibrium quantum phase transition via entanglement decoherence dynamics.

We investigate the decoherence dynamics of continuous variable entanglement as the system-environment coupling strength varies from the weak-coupling to the strong-coupling regimes. Due to the existence of localized modes in the strong-coupling regime, the system cannot approach equilibrium with its environment, which induces a nonequilibrium quantum phase transition. We analytically solve the entanglement decoherence dynamics for an arbitrary spectral density.

Arabidopsis HFR1 is a potential nuclear substrate regulated by the Xanthomonas type III effector XopD(Xcc8004).

XopDXcc8004, a type III effector of Xanthomonas campestris pv. campestris (Xcc) 8004, is considered a shorter version of the XopD, which lacks the N-terminal domain. To understand the functions of XopDXcc8004, in planta, a transgenic approach combined with inducible promoter to analyze the effects of XopDXcc8004 in Arabidopsis was done.