Dehydration increases sodium-dependent glutamate uptake by hypothalamic paraventricular nucleus synaptosomes.

Objectives: The purpose of this study was to identify and characterize Na+-dependent, high affinity glutamate transporter (GLUT) activity in the hypothalamic paraventricular nucleus (PVN) and to compare GLUT activity in PVN of euhydrated versus water-deprived rats.

Methods: Sprague-Dawley rats were deprived of water for two days before sacrifice. Control rats received water ad libitum.