Publications by authors named "Pei-Ying Zou"
Background: The early diagnosis and treatment of Heliobacter pylori (H.pylori) gastrointestinal infection provide significant benefits to patients. We constructed a convolutional neural network (CNN) model based on an endoscopic system to diagnose H.
View Article and Find Full Text PDFArticle Synopsis
- Bismuth quadruple therapy (BQT) effectively eradicates Helicobacter pylori infection, but its impact on gut microbiota and the role of fecal microbiota transplant (FMT) post-therapy remains less understood.
- A randomized controlled trial conducted in China involved 30 H. pylori-positive patients who received either FMT or a placebo after 14 days of BQT, with stool samples analyzed to assess changes in gut microbiota.
- Results showed that BQT temporarily decreased beneficial gut bacteria and increased pathogenic ones, with both groups returning to baseline gut flora levels by Week 10, and the FMT group showing reduced gastrointestinal symptoms compared to the placebo group by Week 3.
Background: Potassium-competitive acid blockers (P-CAB) are recommended for the treatment of Helicobacter pylori infections, but dual therapy of P-CAB with amoxicillin has been poorly studied. The current study compared the efficacy, adverse reactions, compliance, and effects on gut microbiota of 14-day vonoprazan-amoxicillin (VA) dual therapy with esomeprazole, bismuth potassium citrate, amoxicillin, and metronidazole (EBAM) quadruple therapy in treatment-naive patients with H. pylori.
View Article and Find Full Text PDFArticle Synopsis
- * A total of 146 patients with previous treatment failures were enrolled in a randomized controlled trial, receiving either HDDT (high doses of esomeprazole and amoxicillin) or various regimens based on individual bacterial resistance for CB-SGT, all for 14 days.
- * Eradication rates for HDDT and CB-SGT were comparable, both around 84.9%, with HDDT achieving slightly higher success in patients with certain genetic polymorphisms, but the difference was within acceptable limits
Background: Endoscopic submucosal dissection (ESD) treatment of early esophageal cancer is effective and safe. It is currently the first-line treatment for early esophageal cancer. However, a common side effect is the development of esophageal strictures after ESD.
View Article and Find Full Text PDFBackground: Inconsistent eradication rates for Helicobacter pylori have been reported worldwide with dual therapy, perhaps owing to the difference in dose administration and treatment duration. This retrospective study aimed to determine whether high-dose dual therapy (HDDT) with different regimens leads to different eradication rates. The study compares the efficacy and safety of HDDT 10-day vs 14-day and investigates the factors that might affect the eradication rates.
View Article and Find Full Text PDF