Publications by authors named "Pei-Xin Tan"
Article Synopsis
- * Results indicated that ctDNA levels decreased significantly during treatment and that 27.3% of patients with undetectable ctDNA early in treatment had better survival rates.
- * The findings suggest that ctDNA can be an important indicator of molecular residual disease (MRD) and may help identify patients who could be considered for potential cures based on their treatment response.
Background: As immune checkpoint inhibitors (ICIs) have become widely used in lung cancer treatment, immune-related adverse events (irAEs) warrant sufficient attention. Checkpoint inhibitor-related pneumonitis (CIP) is one of the most concerning adverse events as it is uncommon but life threatening.
Case Summary: The patient whose case is reported here experienced three episodes of CIP in a span of 4 mon.
Radiation-induced Cochlea hair cell death: mechanisms and protection.
Asian Pac J Cancer Prev
January 2015
Cochlea hair cell death is regarded to be responsible for the radiation-induced sensorineural hearing loss (SNHL), which is one of the principal complications of radiotherapy (RT) for head and neck cancers. In this mini- review, we focus on the current progresses trying to unravel mechanisms of radiation-induced hair cell death and find out possible protection. P53, reactive oxygen species (ROS) and c-Jun N-terminal kinase (JNK) pathways have been proposed as pivotal in the processes leading to radiation hair cell death.
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