Sublingual immunotherapy efficacy of Dermatophagoides farinae vaccine in a murine asthma model.

Background: Allergen-specific sublingual immunotherapy is a potential treatment for allergic diseases. Its effective dose and underlying mechanism are still to be explored. Here, we investigated the efficacy and mechanism of sublingually administered Dermatophagoides farinae (Der f) vaccine in a murine asthma model.

[Effects of erythromycin on the synthesis of interleukin-8 and gamma-glutamylcysteine synthetase induced by 4-hydroxynonenal in the bronchial epithelial cells].

Objective: This study was to explore the role of erythromycin on the synthesis of interleukin-8 (IL-8) and gamma-GCS treated by 4-hydroxynonenal (4-HNE) in bronchial epithelial cells (16-HBE).

Method: (1) The experiment groups were divided into 10 micromol/L 4-HNE and control groups. The phosphorylation of ERK-1, JNK, P38MAPK and the combining activity of AP-1 after 10 micromol/L 4-HNE stimulating for 0.

[Changes of signal transducer and transcriptional activator 5 (STAT5) in proliferative splenocytes from asthma mice induced by ovalbumin].

Aim: To investigate the changes of signal transducer and transcriptional activator 5 (STAT5) in proliferative splenocyte of asthma mice.

Methods: BALB/c mice were induced to develop asthma by intraperitoneal injection and then nebulized aspiration of OVA. The splenocytes were isolated, and the proliferation of the splenocytes was detected by MTT colorimetry.

[Effects of H1 blocker and inhaled corticosteroids on asthmatic patients with allergic rhinitis].

Objective: To evaluate the therapeutic effects of H(1) blocker in combination with low dose inhaled corticosteroid on allergic asthma.

Methods: A multi-center, double blind, randomized, placebo control study was conducted in 67 patients with mild to moderate allergic asthma. Patients were randomized to receive either Loratadine 10 mg or placebo twice a day on the basis of inhaled beclomethasone dipropionate (400 microg/d for 14 days, then reduced to 200 microg/d) for 5.