Publications by authors named "Pei-Ting Wang"
Article Synopsis
- Cancer cells have higher levels of reactive oxygen species (ROS) and are more susceptible to therapies that generate ROS, like ascorbic acid (HAsc), but effectiveness is limited by the need for high doses.
- The study introduces nitrogen-doped graphene oxide dots (NGODs) as a biocompatible catalyst that enhances HAsc therapy at manageable concentrations by generating additional ROS and depleting intracellular glutathione (GSH), which contributes to cancer cell damage.
- NGODs can also function as photosensitizers in photodynamic therapy, producing ROS when illuminated, leading to a promising new treatment that combines NGODs and HAsc for more effective tumor destruction while maintaining a high survival rate of normal cells.
Since the first clinical cancer treatment in 1978, photodynamic therapy (PDT) technologies have been largely improved and approved for clinical usage in various cancers. Due to the oxygen-dependent nature, the application of PDT is still limited by hypoxia in tumor tissues. Thus, the development of effective strategies for manipulating hypoxia and improving the effectiveness of PDT is one of the most important area in PDT field.
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