Metabolomics Analysis Reveals Molecular Signatures of Metabolic Complexity in Children with Hypercholesterolemia.

Despite the importance of hypercholesterolemia in children, it is overlooked, and there are currently few metabolomics-based approaches available to understand its molecular mechanisms. Children from a birth cohort had their cholesterol levels measured with the aim of identifying the metabolites for the molecular biological pathways of childhood hypercholesterolemia. One hundred and twenty-five children were enrolled and stratified into three groups according to cholesterol levels (acceptable, <170 mg/dL, = 42; borderline, 170-200 mg/dL, = 52; and high, >200 mg/dL, = 31).

Retinal Thickness Associates with Cognition Dysfunction in Young Adult with Type 1 Diabetes in Taiwan.

Background: Several factors could affect the cognitive dysfunction in patients with type 1 diabetes (T1D).

Objectives: To report the characteristic of cognitive dysfunction in T1D and find its association with the retinal thickness.

Subjects: We recruited one hundred and seven patients with T1D in our study.