Publications by authors named "Pei-Shih Kao"
Int Immunopharmacol
February 2024
Article Synopsis
- Streptococcus pneumoniae is a major pathogen that causes serious infections like pneumonia and meningitis, especially in people with weakened immune systems, and antibiotic resistance is becoming a critical global health issue.
- Researchers are exploring alternative treatments, like monoclonal antibody therapy, targeting a surface protein called spEno1 that contributes to the bacteria's ability to infect.
- Using phage display technology, scientists generated specific antibodies (scFv) against spEno1, demonstrating that these antibodies can effectively inhibit the bacteria's harmful interactions with human plasminogen, indicating potential as a new immunotherapy for pneumococcal infections.
