First 24-Hour Potassium Concentration and Variability and Association with Mortality in Patients Requiring Continuous Renal Replacement Therapy in Intensive Care Units: A Hospital-Based Retrospective Cohort Study.

Serum potassium (K+) levels between 3.5 and 5.0 mmol/L are considered safe for patients.

Explainable Machine Learning-Based Risk Prediction Model for In-Hospital Mortality after Continuous Renal Replacement Therapy Initiation.

In this study, we established an explainable and personalized risk prediction model for in-hospital mortality after continuous renal replacement therapy (CRRT) initiation. This retrospective cohort study was conducted at Changhua Christian Hospital (CCH). A total of 2932 consecutive intensive care unit patients receiving CRRT between 1 January 2010, and 30 April 2021, were identified from the CCH Clinical Research Database and were included in this study.

The Inhibition of Wnt Restrain KRAS-Driven Metastasis in Non-Small-Cell Lung Cancer.

The mutations have been an obstacle to identify therapeutic targets in cancer treatment. In this work, we clarified the distinct metastasis pattern of non-small-cell lung carcinoma (NSCLC) induced by KRAS/KRAS mutations and inhibited the KRAS mediated metastasis by Wnt inhibitor. First, we found that KRAS induced more aggressive phenotype in vitro and in vivo experiments.

Ovatodiolide isolated from Anisomeles indica induces cell cycle G2/M arrest and apoptosis via a ROS-dependent ATM/ATR signaling pathways.

Ovatodiolide was isolated from the traditional Chinese medicinal herb Anisomeles indica, possesses anti-bacterial and anti-inflammatory properties; however, the anti-cancer activity and its mechanisms have been limitedly reported. This study aimed to examine the effect and molecular action of ovatodiolide in lung cancer cells. Cell cycle distribution and reactive oxygen species (ROS) generation were measured by flow cytometry.

Osteoprotegerin genetic polymorphisms and age of symptom onset in ankylosing spondylitis.

Objectives: Osteoporosis is one of the recognized features of AS. It is known that RANK ligand (RANKL), which binds to RANK, can cause the activation of bone resorption. Osteoprotegerin (OPG) also competes with RANK by binding to RANKL and inhibiting bone absorption.

[An experience of nursing a client with myasthenia gravis].

Myasthenia gravis is an autoimmune disease. It causes the formation of certain antibodies that attack acetylcholine receptors. The consequent reduction in the number of acetylcholine receptors causes impairment in the transduction of neural pulses (Cross, 1999).