Publications by authors named "Pei-Lun Yu"
Article Synopsis
- Pseudorabies virus (PRV) is a disease-causing virus primarily affecting pigs, with emerging evidence of human infections, and its relationship with RNA modifications is being explored.
- The study found that mA modification was prominent in PRV transcripts and that manipulating certain host proteins significantly influenced PRV replication; inhibiting or enhancing these proteins affected the virus's ability to replicate.
- Overall, the research suggests that mA modification plays a crucial role in facilitating PRV replication and gene expression, highlighting its dynamic interaction with host cells.
N -methyladenosine (m A) modification is the most common and reversible posttranscriptional modification of RNA in eukaryotes, which is mainly regulated by methyltransferase, demethylase, and specific binding protein. The replication of the virus and host immune response to the virus are affected by m A modification. In different kinds of viruses, m A modification has two completely opposite regulatory functions.
View Article and Find Full Text PDFAntiangiogenic therapy is widely administered in many cancers, and the antiangiogenic drug sorafenib offers moderate benefits in advanced hepatocellular carcinoma (HCC). However, antiangiogenic therapy can also lead to hypoxia-driven angiogenesis and immunosuppression in the tumor microenvironment (TME) and metastasis. Here, we report the synthesis and evaluation of NanoMnSor, a tumor-targeted, nanoparticle drug carrier that efficiently codelivers oxygen-generating MnO and sorafenib into HCC.
View Article and Find Full Text PDFAbnormal tumour vasculature has a significant impact on tumour progression and response to therapy. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis and, thus, can be delivered to normalize tumour vasculature. However, a NO-delivery system with a prolonged half-life and a sustained release mechanism is currently lacking.
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