Publications by authors named "Pei-Lun Xiao"
Article Synopsis
- - The study aimed to investigate how melatonin influences autophagy in cortical neurons of neonatal rats suffering from hypoxic-ischemic brain damage (HIBD), focusing on the PI3K/AKT signaling pathway for potential clinical implications.
- - Neonatal rats were split into three groups: a sham operation, an HIBD group, and one treated with melatonin. Various techniques, including staining and Western blot analysis, were used to assess neuron morphology and autophagy-related proteins.
- - Results showed that melatonin treatment improved neuron structure and reduced autophagy markers in the melatonin group compared to the HIBD group, while also enhancing the activation of the PI3K/AKT pathway.
Article Synopsis
- The study aimed to assess how N-acetylserotonin (NAS) helps protect the retina from damage caused by ischemia-reperfusion injury (RIR) in rats, focusing on specific signaling pathways.
- Researchers used a rat model, dividing the rats into different groups to compare the effects of NAS treatment against RIR, and various techniques were employed to measure cell damage and inflammatory responses.
- Results showed that NAS reduced retinal swelling and increased the survival of retinal ganglion cells, while also decreasing certain inflammatory markers and signaling pathway activations, suggesting its potential as a therapeutic option for retinal conditions.
[Protective effect of melatonin against oxygen-induced retinopathy: a study based on the HMGB1/NF-κB/NLRP3 axis].
Zhongguo Dang Dai Er Ke Za Zhi
June 2023
Objectives: To study the protective effect of melatonin (Mel) against oxygen-induced retinopathy (OIR) in neonatal mice and the role of the HMGB1/NF-κB/NLRP3 axis.
Methods: Neonatal C57BL/6J mice, aged 7 days, were randomly divided into a control group, a model group (OIR group), and a Mel treatment group (OIR+Mel group), with 9 mice in each group. The hyperoxia induction method was used to establish a model of OIR.
Unlabelled: The association between socioeconomic status (SES) and bone mineral density (BMD) in men remains controversial. We showed that SES was positively associated with BMD in American men. Confounding factors like race/ethnicity and age could affect the association.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates osteoporosis prevalence and treatment rates in patients undergoing total joint arthroplasty (TJA), highlighting the increased risk due to age and gender.
- The research found a pooled prevalence of osteoporosis at 24.8% and osteopenia at 38.5%, with higher rates in postmenopausal females.
- Despite the high prevalence, only 32.9% of TJA patients received osteoporosis treatment, indicating a significant treatment gap that needs addressing.