Publications by authors named "Pei-Lu Kao"
Article Synopsis
- Advanced head and neck squamous cell carcinoma (HNSCC) shows a high expression level of the epidermal growth factor receptor (EGFR), which is linked to metastasis, though the role of RNA-binding proteins (RBPs) in this process is not well understood.
- This study identifies two RBPs, nucleolin (NCL) and hnRNPA2B1, as key players in promoting the mesenchymal phenotype of HNSCC and notes that reducing their levels can significantly decrease EGF-induced metastasis.
- Furthermore, the research suggests that these RBPs regulate the stability of the fibronectin mRNA through specific pathways, facilitating tumor cell attachment to blood vessels and enhancing the likelihood of metastasis, especially
