PldA modulates TNFR1-mediated p38 signaling pathways to regulate macrophage responses for its survival.

, a dominant member of the gastric microbiota was associated with various gastrointestinal diseases and presents a significant challenge due to increasing antibiotic resistance. This study identifies 's phospholipase A (PldA) as a critical factor in modulating host macrophage responses, facilitating 's evasion of the immune system and persistence. PldA alters membrane lipids through reversible acylation and deacylation, affecting their structure and function.