Aspergilolide, a steroid lactone produced by an endophytic fungus . MBL1612 isolated from .

A new steroid lactone aspergilolide (), and nine known compounds helvolic acid (), verruculogen (), tryprostatin B (), 13-oxofumitremorgin B (), fumitremorgin C (), demethoxy fumitremorgin C (), terezine D (), aszonalenin (), 12, 13-dihydroxy-fumitremorgin C () from cultures of the endophytic fungus . MBL1612. Their chemical structures were determined by a series of extensive spectroscopic methods.

Aspergilates A to E, second metabolites from Aspergillus sp. isolated from Paeonia ostii.

Five novel globoscinic acid derivatives, aspergilates A-E (1-5) have been isolated from endophytic fungus Aspergillus sp. derived from Paeonia ostii. The structures of aspergilates A-E were determined by in-depth analyses of NMR spectra, HRESIMS and CD experiments.

[Application of high fibular osteotomy in the treatment of knee osteoarthritis].

Objective: To evaluate the short-and mid-term curative effect of high fibular osteotomy on knee osteoarthritis.

Methods: From October 2014 to July 2016, 76 patients with knee osteoarthritis were treated with high fibular osteotomy. There were 22 males and 54 females, ranging in age from 47 to 82 years old, with an average of 61.

Synovial Fluid Macrophage Migration Inhibitory Factor Levels Correlate with Severity of Self-Reported Pain in Knee Osteoarthritis Patients.

BACKGROUND Inflammation is considered as one of the main pathogeneses in OA-induced pain. Macrophage migration inhibitory factor (MIF) is a well known pro-inflammatory cytokine. We aimed to determine whether MIF levels in serum and synovial fluid (SF) are associated with severity of OA-induced pain.