Publications by authors named "Pei-Liang Fu"
Osteoarthritis (OA) affects approximately 12% of the aging Western population. The sirtuin/forkhead box O (SIRT/FOXO) signaling pathway plays essential roles in various biological processes. Despite it has been demonstrated that ubiquitin-specific protease 3 (USP3) inhibits chondrocyte apoptosis induced by interleukin (IL)-1β, the role of USP3/SIRT3/FOXO3 in the senescence of chondrocytes in OA is unclear.
View Article and Find Full Text PDFGiant-cell tumor (GCT) of the bone is an invasiveness and high recurrent bone tumor that is considered borderline or potentially malignant. To explore the molecular mechanism leading to bone destruction and identify novel targets for treatment, we conducted silencing of miR-223 and miR-19a in stromal giant cells and identified TWIST and Runx2 as their target genes. We investigated the impact of these microRNAs and their target genes on stromal giant cells that promote the differentiation of monocyte/macrophages into osteoclast cells and recruitment to the bone microenvironment, which in turn enhances the bone destruction capacity of GCT.
View Article and Find Full Text PDFPigmented Villonodular Synovitis (PVNS) is a relatively rare, benign proliferation lesion of the synovium of large joints. The etiology is varied and unclear. We had report a 79-year-old woman had PVNS after 14 years right hip arthroplasty with metal prosthesis.
View Article and Find Full Text PDFBackground: To evaluate the effect of drainage tube on prognosis after total knee arthroplasty (TKA) and explore an effective treatment with favorable prognosis.
Methods: In a prospective study, 18 patients with TKA for the first time were included and randomly divided into three groups, group A (no placement of drainage tube), group B (negative pressure drainage), and group C (4 h clamping drainage). Intraoperative and postoperative blood loss, operation time, and the drainage volume were recorded and analyzed.
Article Synopsis
- - The study aimed to evaluate the effectiveness of extended release manipulation of the posterior knee clearance during total knee arthroplasty (TKA) on joint function and range of motion compared to a standard procedure.
- - A total of 120 patients with knee osteoarthritis were divided into an experimental group (who received extended manipulation) and a control group (who only had osteophyte cleaning), with significant differences found in extension clearance and recovery times for knee flexion post-surgery.
- - Results indicated that while both groups had similar flexion clearance, the experimental group achieved better extension clearance and had faster recovery of knee flexion range at the 3-month follow-up, with no issues of femoral component loosening observed in either
Objective: To compare the results of primary total knee arthroplasty with patellar reshaping or resurfacing.
Methods: One hundred thirty-three patients were randomized into patellar reshaping group and patellar resurfacing group. Patellar reshaping includes resecting the partial lateral facet of the patella and the osteophytes surrounding the patella, trimming the patella to match the trochlea of the femoral component.
Objective: To assess the outcome of patients with Vancouver type B2 periprosthetic fractures treated with femoral revision using an uncemented extensively porous-coated implant.
Methods: From October 2002 to May 2007, a retrospective clinical and radiographic assessment of 10 patients with Vancouver type B2 periprosthetic fractures treated with femoral revision was evaluated, among which 4 was cement fixation, 6 was non-cement fixation in the index procedure.
Results: The mean follow-up for these patients was 44 months (range, 12 to 67 months).