The Aloe vera acemannan polysaccharides inhibit phthalate-induced cell viability, metastasis, and stemness in colorectal cancer cells.

Plasticizers are recognized as environmental pollutants that may be associated with a range of health concerns, including impacts on growth, development, and oncogenic risks. Previous research demonstrated that prolonged exposure to di-(2-ethylhexyl) phthalate and its metabolite mono-(2-ethylhexyl) phthalate contributes to chemotherapeutic drug resistance and stemness in colorectal cancer cells. Aloe vera, an herbaceous plant with a long-standing history in traditional medicine, has attracted considerable attention for its diverse pharmacological properties.

Delta Immature Platelet Fraction Is Associated With Mortality in Bacteremia Patients.

Objectives: Immature platelet fraction (IPF) for differentiating bacteremia has been explored, whereas its prognostic correlation remains uncertain. This study aims to confirm the predictive capability of IPF for bacteremia and investigate its association with prognosis.

Methods: Patients with complete blood count (CBC) on the blood culture day (D1) and the preceding day (D0) were retrospectively recruited and categorized into bacteremia and nonbacteremia groups.

Lineage switch of KMT2A-rearranged adult B-lineage acute lymphoblastic leukemia following bispecific T-cell engager and monoclonal antibody therapy.

Adult B-lineage acute lymphoblastic leukemia (B-ALL) with t(4;11)(q21;q23) is very rare. It is characterized by mixed-lineage leukemia and has the potential for lineage switching during the treatment course. We report the disease course of a patient with B-ALL with t(4;11)(q21;q23) to demonstrate that close monitoring of cell morphology and immunophenotyping is necessary to capture the lineage switch at an early stage.

Long-term DEHP/MEHP exposure promotes colorectal cancer stemness associated with glycosylation alterations.

Plasticizers are considered as environmental pollution released from medical devices and increased potential oncogenic risks in clinical therapy. Our previous studies have shown that long-term exposure to di-ethylhexyl phthalate (DEHP)/mono-ethylhexyl phthalate (MEHP) promotes chemotherapeutic drug resistance in colorectal cancer. In this study, we investigated the alteration of glycosylation in colorectal cancer following long-term plasticizers exposure.

Curcumin analog, GO-Y078, induces HO-1 transactivation-mediated apoptotic cell death of oral cancer cells by triggering MAPK pathways and AP-1 DNA-binding activity.

Background: GO-Y078, a new synthetic analogue of curcumin (CUR), has higher oral bioavailability and anticancer activity than CUR, but the oncostatic effect of GO-Y078 on oral squamous cell carcinoma (OSCC) is largely unknown.

Research Design And Methods: In the present study, we examined the oncostatic properties and possible mechanisms of GO-Y078 on human SCC-9 and HSC-3 OSCC cells.

Results: Our results indicated that GO-Y078 showed a cytostatic effect against OSCC cells, and this antiproliferative phenomenon stemmed from a mechanism involving multiple levels of cooperation, including cell-cycle G/M arrest and apoptosis induction.

Bioinformatics Analyses Identify the Therapeutic Potential of ST8SIA6 for Colon Cancer.

Sialylation of glycoproteins is modified by distinct sialyltransferases such as ST3Gal, ST6Gal, ST6GalNAc, or ST8SIA with α2,3-, α2,6-, or α2,8-linkages. Alteration of these sialyltransferases causing aberrant sialylation is associated with the progression of colon cancer. However, among the ST8- sialyltransferases, the role of ST8SIA6 in colon cancer remains poorly understood.

Internet-based cognitive behavioural therapy programme with and without videoconference guidance sessions: A randomized controlled trial to treat work-related symptoms of anxiety and depression.

This study provides the results from the implementation of a highly structured therapist-guided iCBT programme for people with work-related anxiety and depression, in terms of programme efficacy, participants' adherence and satisfaction. Seventy-seven national police workers were randomly allocated to one of two groups: without additional videoconference sessions (web platform with guidance of therapist) and with additional videoconference sessions (same intervention as the previous group, plus two videoconference guidance sessions with a psychologist). The intervention was composed of 12 sessions and took place for 17-20 weeks.

Associations of Genetic Polymorphisms with Statuses and Cancer Clinicopathologic Development in Lung Adenocarcinoma Patients.

Lung adenocarcinoma (LADC) is a major subtype of lung cancer, particularly among populations of East Asia. The epidermal growth factor receptor (EGFR) is the most frequently mutated oncogene promoting LADC progression and can serve as a therapeutic target in LADC. The tissue inhibitor of metalloproteinases (TIMP)-3 is a major regulator of extracellular matrix turnover via targeting of matrix metalloproteinases (MMPs), and thus, plays a critical role in tumor development and progression.

Iron Deficiency in Menstruating Adult Women: Much More than Anemia.

Iron deficiency anemia (IDA) is highly prevalent in women of child-bearing age. However, their nonhematological symptoms have been overlooked. This study aims to analyze the nonhematological features and symptoms of IDA in a group of women of reproductive age and the changes occurred during iron therapy.

A multistage adaptive test of fluid intelligence.

Background: Multistage adaptive testing has recently emerged as an alternative to the computerized adaptive test. The current study details a new multistage test to assess fluid intelligence.

Method: An item pool of progressive matrices with constructed response format was developed, and divided into six subtests.

Hippocampal structure and human cognition: key role of spatial processing and evidence supporting the efficiency hypothesis in females.

Here we apply a method for automated segmentation of the hippocampus in 3D high-resolution structural brain MRI scans. One hundred and four healthy young adults completed twenty one tasks measuring abstract, verbal, and spatial intelligence, along with working memory, executive control, attention, and processing speed. After permutation tests corrected for multiple comparisons across vertices ( < .

Effect of silymarin on curcumin-induced mortality in zebrafish (Danio rerio) embryos and larvae.

In presence of 7.5 microM of curcumin, no embryos or larva of zebrafish survived 3 days of incubation; however, coincubation with 144 microg/ml silymarin increased the survival rates of curcumin-treated embryos and larvae to about 70%. Moreover, in presence of 12.

Performance as a function of ability, resources invested, and strategy used.

Computerized tasks allow a more fine-grained analysis of the strategy deployed in a task designed to map a specific ability than the usual assessment on the basis of only the level of performance. Manipulations expected to impair performance sometimes do not have that effect, probably because the level of performance alone can confound the assessment of the ability level if researchers ignore the strategy used. In a study with 1,872 participants, the authors applied the Spatial Orientation Dynamic Test-Revised (J.

[Convergent validity of two tests of conscientiousness].

Convergent validity of two tests of conscientiousness. The absence of correspondence between objective measurement of behavior and measurement based on self-report along with generalized use of questionnaires as personality assessment instruments raises a problem with regard to the validity of assessment instruments in this area of study. The goal of this work is to obtain a convergent validity measure for an objective assessment computerized task of conscientiousness based on the development of a functional equally but morphologically different task.

Influence of impulsivity-reflexivity when testing dynamic spatial ability: sex and g differences.

This work analyzes the possibility that the differences in the performance of men and women in dynamic spatial tasks such as the Spatial Orientation Dynamic Test-Revised (SODT-R; Santacreu & Rubio, 1998), obtained in previous works, are due to cognitive style (Reflexivity-Impulsivity) or to the speed-accuracy tradeoff (SATO) that the participants implement. If these differences are due to cognitive style, they would be independent of intelligence, whereas if they are due to SATO, they may be associated with intelligence. In this work, 1652 participants, 984 men and 668 women, ages between 18 and 55 years, were assessed.

Solution strategies as possible explanations of individual and sex differences in a dynamic spatial task.

When individuals perform spatial tasks, individual differences emerge in accuracy and speed as well as in the response patterns used to cope with the task. The purpose of this study is to identify, through empirical criteria, the different response patterns or strategies used by individuals when performing the dynamic spatial task presented in the Spatial Orientation Dynamic Test-Revised (SODT-R). Results show that participants can be classified according to their response patterns.

Fluid intelligence, working memory and executive functioning.

The causes underlying the correlation between working memory and fluid intelligence remain unknown. There are some researchers who argue that the answer can be found on the presumed executive component of working memory. However, the available empirical evidence is far from conclusive.

The real relationship between short-term memory and working memory.

Storage-oriented memory span tasks with no explicit concurrent processing are usually referred as short-term memory (STM) tasks, whereas tasks involving storage plus concurrent processing requirements are designated as working memory (WM) tasks. The present study explores a question that remains unsolved: Do STM and WM tasks clearly tap distinguishable theoretical constructs? For that purpose, a large sample of 403 participants was tested through 12 diverse memory span tasks. Half of those tasks are widely accepted as measures of STM, whereas the other half measure WM.

Enhancing stability and oxidation activity of cytochrome C by immobilization in the nanochannels of mesoporous aluminosilicates.

Hydrothermally stable and structrurally ordered mesoporous and microporous aluminosilicates with different pore sizes have been synthesized to immobilize cytochrome c (cyt c): MAS-9 (pore size 90 A), MCM-48-S (27 A), MCM-41-S (25 A), and Y zeolites (7.4 A). The amount of cyt c adsorption could be increased by the introduction of aluminum into the framework of pure silica materials.

Complex span tasks, simple span tasks, and cognitive abilities: a reanalysis of key studies.

There is great interest in the relationships between memory span tasks and cognitive abilities. However, the causes underlying their correlation remain unknown. In the present article, five key data sets were reanalyzed according to two criteria: They must consider complex span tasks (so-called working memory [WM] tasks) and simple span tasks (so-called short-term memory [STM] tasks), and they must comprise cognitive ability measures.

Interference caused by the contents of serum separator tubes in the Vitros CRP assay.

Background: We have observed discrepancies between C-reactive protein (CRP) measured in serum prepared from a serum separator tube (SST) and that obtained from a plain tube, when using the Vitros CRP assay. Our study aimed at elucidating the cause of these discrepancies.

Methods: Eighty-seven specimens from hospitalized patients with various types of inflammatory disease were analysed using a fixed-point immuno-rate method on a Vitros CRP slide.