Publications by authors named "Pei-Cheng Ding"
Article Synopsis
- The research aimed to create a practical and cost-effective rat model for cardiopulmonary bypass (CPB) that simulates clinical cardiac surgery, focusing on cardiac arrest and resuscitation.
- Thirty rats were divided into three groups receiving different types of cardioplegia: histidine-tryptophan-ketoglutarate (HTK), blood cardioplegia (BC), and del Nido (DN), with the CPB procedure lasting one hour followed by observation.
- Results showed that HTK cardioplegia led to lower histopathological scores and reduced inflammatory response compared to BC and DN groups, suggesting it may protect the heart more effectively during CPB.
Objective: A small animal model would be an effective tool for research on the pathophysiology of cardiopulmonary bypass (CPB). However, numerous CPB models do not involve myocardial arrest and resuscitation. The aim of this research is to establish an easily achievable myocardial arrest and resuscitation CPB model through hyperkalemia and landiolol, simulating clinical cardiac surgery.
View Article and Find Full Text PDFCongenital heart defects (CHDs), the most common congenital human birth anomalies, involves complex genetic factors. Wnt/β-catenin pathway is critical for cardiogenesis and proved to be associated with numerous congenital heart abnormities. AXIN2 has a unique role in Wnt/β-catenin pathway, as it is not only an important inhibitor but also a direct target of Wnt/β-catenin pathway.
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