Publications by authors named "Pei-Chen Chiu"
Article Synopsis
- ALT (Alternative Lengthening of Telomeres) uses a recombination mechanism to maintain telomere length without telomerase, though the initiation of ALT is still not fully understood.
- Research shows that depleting TERRA, a type of RNA found at telomeres, impacts the formation and maintenance of ALT structures like PML bodies and telomere length.
- TERRA interacts with DNA repair proteins, particularly XPF, which is crucial for activating a DNA damage response that facilitates homologous recombination and telomere lengthening in ALT cells.
