Publications by authors named "Pei-An Lo"
Background: Retinal degeneration is a major cause of irreversible blindness. Stimulation with controlled low-level electrical fields, such as transcorneal electrical stimulation (TES), has recently been postulated as a therapeutic strategy. With promising results, there is a need for detailed molecular characterization of the therapeutic effects of TES.
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- - This study explores transcorneal electrical stimulation (TES) as a method to protect photoreceptors in the retina against degeneration by inducing electric fields, which has not been thoroughly examined in living organisms.
- - Researchers created a computational model of a rat's head to simulate the electric fields and then validated it through experiments on Royal College of Surgeon (RCS) rats, finding specific stimulation amplitudes necessary to achieve effective current density levels for neuroprotection.
- - The results indicate that the computational modeling developed in this research can help optimize electrode designs and stimulation parameters, providing a cost-effective way to improve future studies on TES without needing extensive live testing.
Ultrasonic Retinal Neuromodulation and Acoustic Retinal Prosthesis.
Micromachines (Basel)
October 2020
Ultrasound is an emerging method for non-invasive neuromodulation. Studies in the past have demonstrated that ultrasound can reversibly activate and inhibit neural activities in the brain. Recent research shows the possibility of using ultrasound ranging from 0.
View Article and Find Full Text PDFWe demonstrate dual modality of free-space fluorescence diffuse optical tomography (FDOT) and handheld ultrasound (US) imaging to reveal both functional and structural information in small animals. FDOT is a noninvasive method for examining the fluorophore inside an object from the light distribution of the surface. In FDOT, a 660-nm continuous wave diode laser was used as an excitation source and an electron-multiplying charge-coupled device (EMCCD) was used for fluorescence data acquisition.
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