Publications by authors named "Pei Zhu 朱培"

Following injury, skeletal muscle undergoes repair via satellite cell (SC)-mediated myogenic progression. In SCs, the circadian molecular clock gene, Bmal1, is necessary for appropriate myogenic progression and repair with evidence that muscle molecular clocks can also affect force production. Utilizing a mouse model allowing for inducible depletion of Bmal1 within SCs, we determined contractile function, SC myogenic progression and muscle damage and repair following eccentric contractile-induced injury.

View Article and Find Full Text PDF

Background: Low-density lipoprotein cholesterol (LDL-C) is a well-recognized risk factor for cardiovascular diseases. However, several clinical studies demonstrated an inverse association between LDL-C and mortality risk in patients with acute myocardial infarction (AMI), known as the lipid paradox. This study aims to investigate the potential impact of inflammation on the association between LDL-C levels and mortality risks.

View Article and Find Full Text PDF
Article Synopsis
  • Peripheral artery disease (PAD) affects mobility due to reduced blood flow caused by atherosclerosis, and studies indicate that disruptions in circadian rhythms may impact vascular repair, particularly in limb ischemia situations.
  • This study explores the impact of the skeletal muscle circadian clock on adaptations to ischemic stress using a mouse model, focusing on the role of the circadian clock activator BMAL1 in muscle recovery after surgery-induced limb ischemia.
  • Findings revealed that circadian rhythm-related genes were altered in PAD patients, and the loss of BMAL1 in mice delayed muscle recovery post-ischemia, resulting in fewer regenerated muscle fibers and a decline in specific muscle fiber types.
View Article and Find Full Text PDF

Background: The optimal glycosylated hemoglobin (HbA1c) target in type 2 diabetes mellitus (T2DM) patients remains controversial, especially in patients with concomitant coronary heart disease (CHD). This study aimed to investigate the correlation between baseline HbA1c and long-term prognosis in CHD patients with T2DM.

Methods: The study enrolled 6,839 CHD patients with T2DM and measured HbA1c at admission in a multicenter prospective observational cohort.

View Article and Find Full Text PDF

Collagen, a key extracellular matrix component, is renowned for its biocompatibility, biodegradability, and bioactivity, finding wide applications in food, medicine, cosmetics, and industry. Recombinant collagen expression in Escherichia coli offers advantages such as shorter production cycles and lower costs compared to extraction from animal tissues, though it is known to lack essential post-translational modifications, such as proline hydroxylation, which are crucial for its stability and biological function. Studies have shown that certain prolyl hydroxylases, including BaP4H, DsP4H, and L593, exhibit relatively high modification efficiency in the E.

View Article and Find Full Text PDF

Background: Recent studies have suggested that adverse events associated with lipoprotein(a) [Lp(a)] might be modified by low-density lipoprotein cholesterol (LDL-C) or high-sensitivity C-reactive protein (hs-CRP) levels, but whether LDL-C and hs-CRP jointly mediate the outcome of Lp(a) remains unknown in patients with coronary artery disease.

Methods And Results: A prospective study was conducted, enrolling consecutive 10 724 patients with percutaneous coronary intervention (PCI) in 2013. The endpoint event was all-cause death.

View Article and Find Full Text PDF

Background: Glasgow Prognostic Score (GPS) and its modified counterparts, including the modified GPS (mGPS) and hsCRP-modified GPS (hs-mGPS), are widely used inflammatory indices in clinical settings. Inflammation has gained increased attention in the context of coronary heart disease (CHD); however, its long-term predictive value in patients with CHD remains uncertain.

Objective: This study aimed to assess the predictive values of GPS, mGPS, and hs-mGPS for long-term survival in patients following percutaneous coronary intervention (PCI).

View Article and Find Full Text PDF

Background: Lung cancer is increasing in incidence worldwide, and targeted therapies are developing at a rapid pace. Furthermore, the KRAS specific gene is strongly associated with non-small cell lung cancer (NSCLC). Adult patients with locally advanced or metastatic NSCLC who have tested positive for the KRAS G12C mutation and have progressed after at least one systemic treatment are treated with sotorasib.

View Article and Find Full Text PDF

Background: Recently, the effect of Lipoprotein(a) [Lp(a)] on thrombogenesis has aroused great interest, while inflammation has been reported to modify the Lp(a)-associated risks through an unidentified mechanism.

Purpose: This study aimed to evaluate the association between platelet reactivity with Lp(a) and high-sensitivity C-reactive protein (hs-CRP) levels in percutaneous intervention (PCI) patients treated with clopidogrel.

Methods: Data were collected from 10,724 consecutive PCI patients throughout the year 2013 in Fuwai Hospital.

View Article and Find Full Text PDF

We aim to examine the association between liver function-related indicators and gallstone disease (GSD) risk. The subjects who participated in the China Multicenter Physical Examination Cohort (CMPEC) were enrolled. Relative odds ratios (ORs) with 95% CIs and standardized mean differences (SMDs) were applied to investigate the effect of liver function-related indicators and GSD risk.

View Article and Find Full Text PDF

For air traffic controllers, the extent of their cognitive workload can significantly impact their cognitive function and response time, consequently influencing their operational efficiency or even resulting in safety incidents. In order to enhance the accuracy and efficiency in determining the cognitive workload of air traffic controllers, a cognitive workload detection method for air traffic controllers based on mRMR and fewer EEG channels was proposed in this study. First of all, a set of features related to gamma waves was initially proposed; subsequently, an EEG feature evaluation method based on the mRMR algorithm was employed to pinpoint the most relevant indicators for the detection of the cognitive workload.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how the triglyceride-glucose (TyG) index and high-sensitivity C-reactive protein (hsCRP) relate to major cardiovascular events in patients with chronic coronary syndrome (CCS).
  • Over a 2-year follow-up of 9,421 patients with CCS, a higher risk of major adverse cardiovascular events (MACE) was found in those with elevated TyG levels and hsCRP >3 mg/L.
  • The findings indicate that assessing both TyG and hsCRP together can help identify patients at higher risk for cardiovascular issues, aiding in better management strategies.
View Article and Find Full Text PDF
Article Synopsis
  • Enterovirus G (EV-G) is a member of the Picornaviridae family that infects pigs globally, with 20 genotypes identified, including the newly isolated EV-G/YN29/2022 strain from diarrhea-affected pigs in China.
  • This study found that EV-G/YN29/2022 closely resembles the EV-G6 genotype based on genome sequences, with over 83% similarity, marking it as the first EV-G6 strain recorded in China.
  • Pathogenicity tests showed that this strain led to mild diarrhea, skin lesions, and weight loss, primarily affecting the intestinal tissues, but also appearing in various organs like the brain and liver, contributing valuable insights into EV-G's epidemiology and evolution.
View Article and Find Full Text PDF

Air traffic controllers' mental workload significantly impacts their operational efficiency and safety. Detecting their mental workload rapidly and accurately is crucial for preventing aviation accidents. This study introduces a mental workload detection model for controllers based on power spectrum features related to gamma waves.

View Article and Find Full Text PDF

Purpose: The association between high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) and cardiovascular risk in patients with coronary artery disease remains inconsistent. Recent investigations indicated potential dysfunctionality of HDL under inflammation. This study endeavors to explore whether the inflammatory status modifies the effects of HDL-C and ApoA-I on cardiovascular risk in individuals with percutaneous coronary intervention (PCI).

View Article and Find Full Text PDF

The incidence of eye metastasis from primary malignant tumors is low. Predominantly, these primary malignant tumors consist of breast and lung carcinoma. Ocular metastatic carcinoma is often clinically overlooked.

View Article and Find Full Text PDF

People with lower extremity peripheral artery disease (PAD) have increased oxidative stress, impaired mitochondrial activity, and poor walking performance. NAD+ reduces oxidative stress and is an essential cofactor for mitochondrial respiration. Oral nicotinamide riboside (NR) increases bioavailability of NAD+ in humans.

View Article and Find Full Text PDF

The circadian clock orchestrates vital physiological processes such as metabolism, immune function, and tissue regeneration, aligning them with the optimal time of day. This study identifies an intricate interplay between the circadian clock within muscle stem cells (SCs) and their capacity to modulate the immune microenvironment during muscle regeneration. We uncover that the SC clock provokes time of day-dependent induction of inflammatory response genes following injury, particularly those related to neutrophil activity and chemotaxis.

View Article and Find Full Text PDF

Background: Rehabilitation assessment is a critical component of rehabilitation treatment.

Objective: This study focuses on a comprehensive analysis of patients' movement performance using the upper limb rehabilitation robot. It quantitatively assessed patients' motor control ability and constructed an intelligent grading model of functional impairments.

View Article and Find Full Text PDF

Rationale: Recombinant human endostatin (Endostar) is extensively utilized in China for the clinical management of patients with driver gene-negative non-small cell lung cancer (NSCLC) at stage TNM IV. This report describes the case of a lung cancer patient treated exclusively with Endostar maintenance therapy, who experienced a rapid deterioration in respiratory function.

Patient Concerns: The case involved a patient with a pathologically confirmed squamous cell carcinoma of the left lung, treated in our department.

View Article and Find Full Text PDF

Background: A novel inflammatory marker that measures the degree of systemic immunoinflammation, the systemic immuno-inflammation index (SII) is frequently used to forecast a number of illnesses. According to earlier studies, inflammation may play a role in the pathophysiology of hearing loss (HL).

Methods: A sample from the National Health and Nutrition Examination Survey (NHANES) covering the years 2009 to 2018 was used in the current cross-sectional survey.

View Article and Find Full Text PDF

Neoantigens derived from somatic mutations in Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), the most frequently mutated oncogene, represent promising targets for cancer immunotherapy. Recent research highlights the potential role of human leukocyte antigen (HLA) allele A*11:01 in presenting these altered KRAS variants to the immune system. In this study, we successfully generate and identify murine T-cell receptors (TCRs) that specifically recognize KRAS from three predicted high affinity peptides.

View Article and Find Full Text PDF

Recent research has highlighted an important role for the molecular circadian machinery in the regulation of tissue-specific function and stress responses. Indeed, disruption of circadian function, which is pervasive in modern society, is linked to accelerated aging, obesity, and type 2 diabetes. Furthermore, evidence supporting the importance of the circadian clock within both the mature muscle tissue and satellite cells to regulate the maintenance of muscle mass and repair capacity in response injury has recently emerged.

View Article and Find Full Text PDF