Dementia Care Research and Psychosocial Factors.

Background: Studies show that tube feeding does not improve clinical outcomes, and professional guidelines recommend against its use for individuals with advanced dementia. Yet, our preliminary work demonstrates a preference for tube feeding among Chinese-American dementia caregivers. We propose linguistic and cultural adaptation of "Making Choices: Feeding Options for Patients with Dementia (MCFODA) to create the Chinese version of this efficacious decision aid intervention.

Symmetrical and asymmetrical surface structure expansions of silver nanoclusters with atomic precision.

Controlling symmetrical or asymmetrical growth has allowed a series of novel nanomaterials with prominent physicochemical properties to be produced. However, precise and continuous size growth based on a preserved template has long been a challenging pursuit, yet little has been achieved in terms of manipulation at the atomic level. Here, a correlated silver cluster series has been established, enabling atomically precise manipulation of symmetrical and asymmetrical surface structure expansions of metal nanoclusters.

Denture use and a slower rate of cognitive decline among older adults with partial tooth loss in China: A 10-year prospective cohort study.

Objective: Denture use has been shown to improve nutritional intake and diet quality in people with tooth loss. Despite evidence linking tooth loss and dementia, few studies have examined the association between denture use and cognitive decline. We investigated the relationship between denture use and cognitive decline among Chinese older adults with tooth loss.

Exosomal NEDD4L derived from HG+oxLDL-induced vascular endothelial cells accelerates macrophage M1 polarization and oxLDL uptake by ubiquitinating IκBα and PPARγ.

Background: Vascular endothelial cell-derived exosomes are thought to mediate disease progression by regulating macrophage polarization. However, its mechanism in diabetes mellitus (DM)-related atherosclerosis (AS) progress is unclear.

Methods: High-glucose (HG) and oxLDL were used to induce human cardiac microvascular endothelial cells (HCMECs) to mimic DM-related AS model.

Genetic Risk Factors for Metabolic Dysfunction-Associated Steatotic Liver Disease.

Metabolic dysfunction-associated steatotic liver disease (MASLD), is the most common cause of liver disease, and its burden on health systems worldwide continues to rise at an alarming rate. MASLD is a complex disease in which the interactions between susceptible genes and the environment influence the disease phenotype and severity. Advances in human genetics over the past few decades have provided new opportunities to improve our understanding of the multiple pathways involved in the pathogenesis of MASLD.

Blocking the isoflavone chemoreceptor in to prevent disease.

Inhibiting pathogen chemotaxis is a promising strategy for reducing disease pressure. However, this strategy is currently in the proof-of-concept stage. Here, was used as a model, as its biflagellated zoospores could sense genistein, a soybean root exudate, to navigate host and initiate infection.

Phosphorescent Sensor Based on Iridium(III) Complex with Aggregation-Induced Emission Activity for Facile Detection of Volatile Acids.

Phosphorescent sensors are essential for rapid visual sensing of volatile acids, due to their profound impact on ecosystems and human health. However, solid phosphorescent materials for acid-base stimulus response are still rare, and it is important to achieve real-time monitoring of volatile acids. In order to obtain an efficient and rapid response to volatile acid stimulation, N-H and -NH substituents are introduced into an auxiliary ligand to synthesize a new cationic Ir(III) complex ().

Comparative study of single-port single-channel and single-port multi-channel adrenalectomy in various maximum tumor diameters.

Background: Investigating the application of single-port single-channel and single-port multi-channel adrenalectomy in various maximum tumor diameters.

Methods: Retrospective analysis of clinical data from 218 adrenal tumors treated with single-port retroperitoneoscopic adrenalectomy at Lianyungang Clinical Medical College of Nanjing Medical University from September 2018 to November 2023. All adrenal tumors are benign lesions classified as T1 stage.

Metastatic sites of baseline as predictors in recurrent or metastatic nasopharyngeal carinoma treated with PD-L1 inhibitor: a secondary analysis of multicenter, single-arm, phase II study (KL-A167).

Background: Immune checkpoint inhibitors (ICIs) show optimal treatment effects on recurrent or metastatic nasopharyngeal carcinoma(R/M NPC). Nonetheless, whether metastatic sites impact ICIs efficacy remains unclear.

Methods: We performed a secondary analysis of R/M NPC patients treated with KL-A167, a programmed cell death-ligand 1(PD-L1) inhibitor, based on a multicenter, single-arm, phase II study from China between 2019 and 2021 years, which represents the first and most comprehensive analysis of the effectiveness of a PD-L1 inhibitor in patients who have been previously treated.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

Diagnosis and insight into the unique lung microbiota of pediatric pulmonary tuberculosis patients by bronchoalveolar lavage using metagenomic next-generation sequencing.

Background: Although previous studies have reported the dysregulation of respiratory tract microbiota in infectious diseases, insufficient data exist regarding respiratory microbiota imbalances in the lower respiratory tracts of children with pulmonary tuberculosis (PTB). In this study, we assessed the value of mNGS in the pathogen diagnosis and microbiome analysis of PTB patients using bronchoalveolar lavage fluid (BALF) samples.

Methods: A total of 64 participants, comprising 43 pediatric PTB and 21 pediatric pneumonia patients were recruited in the present study.

L3MBTL3 and STAT3 collaboratively upregulate SNAIL expression to promote metastasis in female breast cancer.

The STAT3 pathway promotes epithelial-mesenchymal transition, migration, invasion and metastasis in cancer. STAT3 upregulates the transcription of the key epithelial-mesenchymal transition transcription factor SNAIL in a DNA binding-independent manner. However, the mechanism by which STAT3 is recruited to the SNAIL promoter to upregulate its expression is still elusive.

Ultra robust negative differential resistance memristor for hardware neuron circuit implementation.

Neuromorphic computing holds immense promise for developing highly efficient computational approaches. Memristor-based artificial neurons, known for due to their straightforward structure, high energy efficiency, and superior scalability, which enable them to successfully mimic biological neurons with electrical devices. However, the reliability of memristors has always been a major obstacle in neuromorphic computing.

Immune-related adverse events as prognostic biomarkers in recurrent or metastatic nasopharyngeal carcinoma receiving PD-L1 inhibitor: A post-hoc analysis of the multicenter, single-arm, phase 2 study.

Background: Immune-related adverse events (irAEs) have been associated with better therapeutic outcomes in patients receiving immune checkpoint inhibitors (ICIs) across various cancers. This study investigates the association between irAEs and ICI outcomes in patients with recurrent or metastatic nasopharyngeal carcinoma (R/M NPC).

Methods: A post hoc analysis was performed on 153 patients with R/M NPC who received anti-PD-L1 inhibitors between February 26, 2019, and January 13, 2021.

Machine Learning-based Prognostic Model for Brain Metastasis Patients: Insights from Blood Test Analysis.

Brain metastases, affecting 30% of solid tumor patients, have a substantial impact on clinical outcomes. Developing a clinically feasible and precise prognostic model is crucial for personalized and comprehensive treatment. Parameters from blood test were collected from brain metastases patients, and were used to construct the four models, including univariate Cox regression, stepwise regression, LASSO regression, and random survival forest (RSF).

Causal factors identification and dynamics simulation of major road traffic accidents from China's evidence: A high-order mixed-method design.

Mitigating the injury and severity of road traffic accidents has become a crucial objective in global road safety efforts. Major road traffic accidents (MRTAs) pose significant challenges due to their high hazard and severe consequences. Despite their widespread impact, the complex causation mechanisms behind MRTAs have not been thoroughly and systematically investigated, which hinders the development of effective control strategies and policies.

Anti-angiogenic activity and mechanism of fucoidan from brown algae, Sargassum Naozhouense mediated by intracellular antioxidation.

Fucoidan has various physiological activities, and its structure is also different according to different brown algae. In this study SNF (Sargassum Naozhouense fucoidan) was extracted by acid extraction method, and its relative molecular weight was determined to be 631.40 kDa.

Comprehensive analysis of transplacental transfer of environmental pollutants detected in paired maternal and cord serums.

Prenatal exposure to hazardous environmental pollutants is a critical global concern due to their confirmed presence in umbilical cord blood, indicating the ability of pollutants to cross the placental barrier and expose the fetus to harmful compounds. However, the transplacental transfer efficiencies (TTEs) of many pollutants remain underexplored. Herein, we developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantitatively analyze 91 environmental pollutants, including 13 bisphenols (BPs), 18 organophosphorus flame retardants (OPFRs), 7 brominated and other flame retardants (BFRs), 34 phthalates (PAEs), and 19 per- and polyfluoroalkyl substances (PFASs), in paired maternal and cord serums.

Multi-Functional Semiconductor Polymer Doped Wide Bandgap Layer for All-Perovskite Solar Cells with High Efficiency and Long Durability.

The study presents a multi-functional and semiconductor polymer poly[bis(3-hexylthiophen-2-yl)thieno[3,4-c]pyrrole-4,6-dione] (PBDTTPD) doping strategy that significantly enhanced the performance of the two-terminal all-perovskite tandem perovskite solar cells (T-PSCs). An optimized power conversion efficiency (PCE) of 26.87% has been achieved.

Low Thermal Conductivity and Diffusivity at High Temperatures Using Stable High-Entropy Spinel Oxide Nanoparticles.

The realization of low thermal conductivity at high temperatures (0.11 W m K 800 °C) in ambient air in a porous solid thermal insulation material, using stable packed nanoparticles of high-entropy spinel oxide with 8 cations (HESO-8 NPs) with a relatively high packing density of ≈50%, is reported. The high-density HESO-8 NP pellets possess around 1000-fold lower thermal diffusivity than that of air, resulting in much slower heat propagation when subjected to a transient heat flux.

Ferrocene-Based Metal-Organic Framework for Adsorption and Degradation of Antibiotics.

Antibiotics have emerged as a significant class of organic pollutants, posing serious global challenges to both the environment and human health. To address the issue of water pollution by antibiotics, a ferrocene-based organic framework (FcMOF) with paramagnetism has been synthesized by hydrothermal complexation of ferrocene dicarboxylic acid with copper chloride and utilized for quick and efficient adsorption and degradation of antibiotics. The maximum adsorption capacity of TC was 736.

Consumer views of functional electrical stimulation and robotic exoskeleton in SCI rehabilitation: A mini review.

Background: Functional electrical stimulation (FES) and robotic exoskeletons represent emerging technologies with significant potential for restoring critical physical functions such as standing and walking-functions that are most susceptible after spinal cord injury (SCI). However, the further development and successful integration of these technologies into clinical practice and daily life require a deep understanding of consumer perspectives.

Objective: This review synthesizes consumer perspectives from a diverse range of technology stakeholders, including medical service providers, researchers, and persons affected by SCI-those living with SCI and their caregivers.

Exploring foreign language anxiety and resting-state EEG alpha asymmetry.

Anxiety experienced when interacting in a foreign language hinders communication through detrimental behavioral, cognitive, and somatic effects. Despite its impact, there is limited research on how neural asymmetry relates to foreign language anxiety (FLA). While researchers have investigated FLA through brain imaging, there remains an absence of studies examining its correlation with frontal alpha asymmetry.