Publications by authors named "Pei Xin Zhang"

Article Synopsis
  • The study examines how well pegylated interferon (PEG-IFNα) therapy can clear hepatitis B surface antigen (HBsAg) in chronic hepatitis B (CHB) patients and identifies factors predicting successful treatment.
  • A systematic review of 102 studies shows low overall HBsAg clearance rates, around 10.6% at the end of treatment and 11.1% after follow-up, with baseline HBsAg levels being the most critical predictor.
  • Higher baseline HBsAg levels (like 100 IU/ml) lead to significantly better clearance rates (up to 53.9%) compared to higher levels (like 10,000 IU/ml, which is only 7.9%), and
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Article Synopsis
  • A model was developed to predict HBeAg seroconversion in patients with chronic hepatitis B after nucleos(t)ide analog therapy, which is important because such models are limited.
  • The study involved 75 patients receiving a year of peginterferon-alfa treatment, analyzing various predictors at different time points to create a scoring system for treatment efficacy.
  • Key predictors at baseline, week 12, and week 24 included specific levels of HBsAg and HBeAg, with the final model showing significant differences in response and clearance rates based on total scores.
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The Quaternary sediment in the Ningbo Coastal Plain was the deposit due to sea-land interaction, which recorded information of past climate changes. The region is therefore an ideal area to study paleoclimate changes and sedimentary characteristics. We determined the stratigraphic division and paleoenvironmental evolution based on C and paleomagnetic dating, along with detailed analyses of lithology, pollen assemblage, foraminifera and ostracodes assemblage, and grain size of sediment in core Z02 located in the southeastern Ningbo Coastal Plain.

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3D hybrid nanostructures connecting 1D carbon nanotubes (CNTs) with 2D graphene have attracted more and more attentions due to their excellent chemical, physical and electrical properties. In this study, we firstly report a novel and facile one-step process using template-directed chemical vapor deposition (CVD) to fabricate highly nitrogen doped three-dimensional (3D) N-doped carbon nanotubes/N-doped graphene architecture (N-CNTs/N-graphene). We used nickel foam as substrate, melamine as a single source for both carbon and nitrogen, respectively.

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Objectives We investigated the effects of CD100 on naïve CD8 T cells during hepatitis C virus (HCV) infection after interferon-α (IFN-α) therapy to clarify the mechanism underlying the effect of IFN-α in enhancing the antiviral response. Methods The CD100 molecules on subsets of CD8 T cells were analysed with flow cytometry. The effects of CD100-overexpressing naïve CD8 T cells were determined with ELISAs and an MTT cytotoxicity assay.

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A series of enantiomeric polypyridyl ruthenium(II) complexes Delta- and Lambda-[Ru(bpy)2CNOIP](PF6)2 (Delta-1 and Lambda-1; BPY=2,2'-bipyridine, CNOIP=2-(2-chloro-5-nitrophenyl)imidazo[4,5-f][1,10]phenanthroline), Delta- and Lambda-[Ru(bpy)2HPIP](PF6)2 (Delta-2 and Lambda-2; HPIP=2-(2-hydroxyphenyl)imidazo[4,5-f][1,10]phenanthroline), Delta- and Lambda-[Ru(bpy)2DPPZ](PF6)2 (Delta-3 and Lambda-3; DPPZ=dipyrido[3,2:a-2',3':c]-phenazine), Delta- and Lambda-[Ru(bpy)2TAPTP](PF6)2 (Delta-4 and Lambda-4; TAPTP=4,5,9,18-tetraazaphenanthreno[9,10-b] triphenylene) have been synthesized. Binding of these chiral complexes to calf thymus DNA has been studied by spectroscopic methods, viscosity, and equilibrium dialysis. The experimental results indicated that all the enantiomers of these complexes bound to DNA through an intercalative mode, but the binding affinity of each chiral complex to DNA was different due to the different shape and planarity of the intercalative ligand.

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