The Effect of Perceived Groove in Music on Effective Brain Connectivity during Cycling: An F-NIRS Study.

Introduction: Perceived groove, a complex and integrated musical characteristic, is considered a core factor in inducing synchronization between movement and music. This study aimed to employ functional near-infrared spectroscopy (fNIRS) to explore the effective connectivity (EC) changes among brain regions during cycling activities under different perceived groove conditions.

Methods: In a randomized crossover design, 18 university students performed 3-min cycling tasks under high (HG) and low (LG) perceived groove music conditions.

Standardized workflow for multiplexed charge detection mass spectrometry on orbitrap analyzers.

Individual ion mass spectrometry (IMS) is the Orbitrap-based extension of the niche mass spectrometry technique known as charge detection mass spectrometry (CDMS). While traditional CDMS analysis is performed on in-house-built instruments such as the electrostatic linear ion trap, IMS extends CDMS analysis to Orbitrap analyzers, allowing charge detection analysis to be available to the scientific community at large. IMS simultaneously measures the mass-to-charge ratios (m/z) and charges (z) of hundreds to thousands of individual ions within one acquisition event, creating a spectral output directly into the mass domain without the need for further spectral deconvolution.

Co/CoO@NC-CNTs modified separator of Li-S battery achieving the synergistic effect of adsorption-directional migration-catalysis via built-in electric field.

The shuttle effect of lithium polysulfides (LiPSs) and sluggish sulfur conversion kinetics have seriously hindered the commercial application of lithium-sulfur (Li-S) batteries. Currently, the adsorption and catalysis processes are emphasized; however, the diffusion process is often neglected. The delayed diffusion of the adsorbed LiPSs significantly reduce battery performance.

Application of platelet transcriptomics for assessing treatment effectiveness and predicting long-term platelet counts recovery in aplastic anemia.

Background: Aplastic anemia (AA) is a bone marrow failure disease for which the means of assessing and predicting the therapeutic effectiveness are still relatively limited. Thrombocytopenia is often the earliest and most severe symptom in patients newly diagnosed with AA. While clinical consideration is usually given to the quantitative changes in platelets during treatment, there is little focus on the resolution of the molecular characteristics of platelets in AA.

Ultrafine MoN Quantum Dots Embedded in N-Doped Graphene Sheets Enable Efficient Adsorption-Catalytic Transformation of Polysulfides.

Because of the high theoretical energy density of 2600 Wh kg, lithium-sulfur batteries (LSBs) are anticipated to be among the next generation of high-energy-density storage technologies. However, the practical application of LSBs has been severely hampered by the significant shuttle effect and slow redox kinetics of polysulfides (LiPSs). To address the above problems, in this paper, the concept of quantum dots (QDs) was introduced to design and synthesize MoN QD-modified N-doped graphene nanosheets (marked as MoN-QDs@NG), which were used as separator modification materials for LSBs.

Correlative Imaging for Comprehensive Molecular Mapping of Individual Cell Types in Biological Tissues.

Mass spectrometry imaging (MSI) is a powerful technique for label-free spatial mapping of multiple classes of biomolecules in tissue sections. However, differences in desorption and ionization efficiency of different classes of molecules make it challenging to simultaneously map biomolecules at each omics layer in the same tissue sample. Herein, we present a correlative imaging method using nanospray desorption electrospray ionization (nano-DESI) MSI, which enables the spatial mapping of lipids, metabolites, peptides, and proteins with cellular-level spatial resolution in a single tissue section.

Synergy of atomic hydrogen reduction and reactive oxygen species oxidation over confined Mn bifunctional site for electrocatalytic deep mineralization.

Traditional reduction or oxidation processes generating one-component free radicals face challenges in deep dechlorination and mineralization of chlorophenols from wastewater. Herein, an efficient electrocatalytic process has been developed, which couples atomic H* reduction with reactive oxidation species (OH and O) oxidation on a bifunctional cathode for 4 -chlorophenol (4 -CP) removal. The N - doped carbon nanotubes encapsulated manganese nanoparticles was fabricated as cathode, which could generate atomic H* , initiating nucleophilic hydrodechlorination in presence of confined MnO sites.

The effect of host size on binding in host-guest complexes of cyclodextrins and polyoxometalates.

Harnessing flexible host cavities opens opportunities for the design of novel supramolecular architectures that accommodate nanosized guests. This research examines unprecedented gas-phase structures of Keggin-type polyoxometalate PWO (WPOM) and cyclodextrins (X-CD, X = α, β, γ, δ, ε, ζ) including previously unexplored large, flexible CDs. Using ion mobility spectrometry coupled to mass spectrometry (IM-MS) in conjunction with molecular dynamics (MD) simulations, we provide first insights into the binding modes between WPOM and larger CD hosts as isolated structures.

Mass spectrometry-based proteomics for advancing solid organ transplantation research.

Scarcity of high-quality organs, suboptimal organ quality assessment, unsatisfactory pre-implantation procedures, and poor long-term organ and patient survival are the main challenges currently faced by the solid organ transplant (SOT) field. New biomarkers for assessing graft quality pre-implantation, detecting, and predicting graft injury, rejection, dysfunction, and survival are critical to provide clinicians with invaluable prediction tools and guidance for personalized patients' treatment. Additionally, new therapeutic targets are also needed to reduce injury and rejection and improve transplant outcomes.

Efficacy of metastatic lesion radiotherapy in patients with metastatic nasopharyngeal carcinoma: A multicenter retrospective study.

Objective: We investigated the efficacy of metastatic lesion radiotherapy (MLRT) in patients with metastatic nasopharyngeal carcinoma (mNPC).

Materials And Methods: Patients with mNPC from three institutions were included in this study. Propensity score matching (PSM) was employed to ensure comparability between patient groups.

New genes helped acorn barnacles adapt to a sessile lifestyle.

Barnacles are the only sessile lineages among crustaceans, and their sessile life begins with the settlement of swimming larvae (cyprids) and the formation of protective shells. These processes are crucial for adaptation to a sessile lifestyle, but the underlying molecular mechanisms remain poorly understood. While investigating these mechanisms in the acorn barnacle, Amphibalanus amphitrite, we discovered a new gene, bcs-6, which is involved in the energy metabolism of cyprid settlement and originated from a transposon by acquiring the promoter and cis-regulatory element.

Effects evaluation of different exercises on subclinical left ventricular dysfunction in obese rats by speckle-tracking echocardiography.

Objective: To identify subclinical left ventricle dysfunction (LVD) in obese rats by speckle-tracking echocardiography, and to evaluate the effects of 12-week Moderate-Intensity Continuous Training (MICT) or High-Intensity Interval Training (HIIT) on LV geometry, histology and function in obese rats.

Methods: Eighteen male standard or obese Sprague-Dawley rats were randomly divided into the Control group, the MICT group, and the HIIT group. Exercise interventions were conducted for 12 weeks, with equal total load and increased intensity gradient.

Cobalt Nitride Nanoparticles Encapsulated in N-Doped Carbon Nanotubes Modified Separator of Li-S Battery Achieving the Synergistic Effect of Restriction-Adsorption-Catalysis of Polysulfides.

Although lithium-sulfur (Li-S) batteries have broad market prospects due to their high theoretical energy density and potential cost-effectiveness, the practical applications still face serious shuttle effects of polysulfides (LiPSs) and slow redox reactions. Therefore, in this paper, cobalt nitride nanoparticles encapsulated in nitrogen-doped carbon nanotube (CoN@NCNT) are prepared as a functional layer for the separator of high-performance Li-S batteries. Carbon nanotubes with large specific surface areas not only promote the transport of ions and electrons but also weaken the migration of LiPSs and confine the dissolution of LiPSs in electrolytes.

Constructing CoNC coordination in CoS embedded N,S-codoped carbon nanotube as an advanced electrode for supercapacitor and Na-ion battery.

Yolk-shell-structured transition metal sulfides (TMSs)/carbon nanocomposites are highly desirable in advanced energy storage system, such as sodium-ion batteries (SIBs) and supercapacitors (SCs). Nevertheless, practical applications are still prevented by the loose attachment of TMSs with carbon caused by conversion stress, the aggregation of TMSs nanoparticles and the sluggish ion transport caused by high crystallinity of carbon. Here, the disperse hollow CoS nanoparticles encapsulated into N,S-codoped carbon nanotubes (CNTs) with poor crystallinity through CoNC bond was synthesized (CS-NSCNT) to overcome the above obstacles.

Identification and characterization of human hematopoietic mesoderm.

The embryonic mesoderm comprises heterogeneous cell subpopulations with distinct lineage biases. It is unclear whether a bias for the human hematopoietic lineage emerges at this early developmental stage. In this study, we integrated single-cell transcriptomic analyses of human mesoderm cells from embryonic stem cells and embryos, enabling us to identify and define the molecular features of human hematopoietic mesoderm (HM) cells biased towards hematopoietic lineages.

Automated imaging and identification of proteoforms directly from ovarian cancer tissue.

The molecular identification of tissue proteoforms by top-down mass spectrometry (TDMS) is significantly limited by throughput and dynamic range. We introduce AutoPiMS, a single-ion MS based multiplexed workflow for top-down tandem MS (MS) directly from tissue microenvironments in a semi-automated manner. AutoPiMS directly off human ovarian cancer sections allowed for MS identification of 73 proteoforms up to 54 kDa at a rate of <1 min per proteoform.

Exercise against nonalcoholic fatty liver disease: Possible role and mechanism of lipophagy.

Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease worldwide. NAFLD is prevalent in about 30% of people worldwide. The lack of physical activity is considered as one of the risks for NAFLD, and approximately one-third of NAFLD patients hardly engage in physical activity.