Publications by authors named "Pei Ran Zhou"
Aim: To investigate the correlation between DKK1 polymorphisms with bone phenotypes and response to alendronate treatment.
Materials & Methods: Five tag single nucleotide polymorphisms of DKK1 were analyzed in 639 Chinese postmenopausal women with osteoporosis or osteopenia. Bone mineral density (BMD), β-CTX and ALP were measured before and after alendronate treatment.
Aim: To investigate the association between SOST gene polymorphisms and response to alendronate treatment.
Materials & Methods: 639 Chinese postmenopausal women with osteoporosis or osteopenia received alendronate treatment. Polymorphisms of SOST were analyzed.
Gorham-Stout disease (GSD) is an exceedingly rare disease characterized by progressive osteolysis and angiomatosis. We investigate the features of this disease and evaluate the effects of bisphosphonates (BPs) on it. The clinical, radiological, and pathological characteristics of 12 patients diagnosed with GSD were summarized.
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- The study aimed to explore how variations in the LRP5 gene affect the effectiveness of alendronate treatment in women with osteoporosis in China.
- The research involved 639 postmenopausal women who were treated with alendronate, and the A1330V polymorphism in LRP5 was examined alongside changes in bone mineral density and bone turnover markers before and after treatment.
- Results showed that women with CC and CT genotypes experienced more significant improvements in lumbar spine bone density and decreases in specific bone turnover markers than those with the TT genotype, indicating that the TT genotype may signal a weaker response to the medication.