Publications by authors named "Pei Pei Yan"
This experiment was designed to investigate the effect of supplementing conjugated linoleic acid (CLA) in breeder hens diet on development and hepatic lipid metabolism of chick offspring. Hy-Line Brown breeder hens were allocated into two groups, supplemented with 0 (control (CT)) or 0·5 % CLA for 8 weeks. Offspring chicks were grouped according to the mother generation and fed for 7 d.
View Article and Find Full Text PDFThe operations involved in preimplantation genetic testing (PGT) occur during the key stages of gametogenesis and early embryonic development, and the health of progeny following PGT (PGT-born) is worthy of attention. In order to fully assess the potential risk of abnormal glucose metabolism in adult PGT-born offspring and to evaluate possible mechanisms, we compared a mouse model of PGT (in vitro cultured embryos with biopsy, hereafter "PTG-born mice"), an in vitro embryo manipulation mouse model (in vitro cultured embryos without biopsy), and normal mice. PGT-born mice displayed increased fasting glucose, and decreased glycogen synthesis and glucose oxidative utilization in the liver.
View Article and Find Full Text PDF[Brief introduction of research methods of commodity specification and grade of Chinese medicinal materials].
Zhongguo Zhong Yao Za Zhi
February 2015
Article Synopsis
- The paper discusses the importance of establishing quality standards for Chinese medicinal materials (TCMs), as these standards directly affect the safety and effectiveness of clinical medicines.
- It reviews various research methods used to assess the quality of TCMs, including sensory evaluation, chemical assessment, and biological evaluation.
- The goal is to provide technical support for standardization and to create a scientific foundation for the rational use of drugs in clinical settings.
[Effects of bisphenol-A on blastocyst development and implantation].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
August 2014
Article Synopsis
- A study was conducted to assess the impact of bisphenol-A (BPA) on the development and implantation of blastocysts in pregnant mice, using various dosages of BPA (100, 300, and 600 mg/(kg·d)).
- Results indicated that high BPA concentrations (300 mg/(kg·d) and above) significantly decreased the number of implantation sites and rates, with the 600 mg/(kg·d) group showing no implantation at all.
- While BPA treatment did not notably affect overall blastocyst development rates, it decreased hatching rates and increased apoptosis (cell death) in blastocysts at higher BPA dosages, indicating potential harm to embryo health.
[Effects of bisphenol A on the female reproductive organs and their mechanisms].
Zhongguo Yi Xue Ke Xue Yuan Xue Bao
December 2013
Article Synopsis
- Bisphenol A (BPA) is an environmental estrogen that is widely used and can disrupt endocrine functions in female mammals.
- Prolonged exposure to BPA is linked to structural and functional changes in reproductive organs such as the ovaries, uterus, vagina, and oviducts.
- The review explores how BPA interacts with different molecular targets in the female reproductive system and examines the potential mechanisms behind these effects.
Alzheimer's disease and osteoporosis are often observed to co-occur in clinical practice. The present study aimed to evaluate the bone microarchitecture and bone mineral density (BMD) of the proximal tibia in APP/PS1 transgenic mice by micro-computed tomography (micro-CT), and to search for evidence that curcumin can be used to reduce bone mineral losses and treat osteoporosis after senile dementia in these transgenic mice. Three-month-old female mice were divided into the following groups (n=9 per group): wild-type mice (WT group); APP/PS1 transgenic mice (APP group); and APP/PS1 transgenic mice with curcumin treatment (APP+Cur group).
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