NFATc3-dependent expression of miR-153-3p promotes mitochondrial fragmentation in cardiac hypertrophy by impairing mitofusin-1 expression.

Mitochondrial dysfunction is involved in the pathogenesis of various cardiovascular disorders. Although mitochondrial dynamics, including changes in mitochondrial fission and fusion, have been implicated in the development of cardiac hypertrophy, the underlying molecular mechanisms remain mostly unknown. Here, we show that NFATc3, miR-153-3p, and mitofusion-1 (Mfn1) constitute a signaling axis that mediates mitochondrial fragmentation and cardiomyocyte hypertrophy.

[Effects of nitrogen fertilization on the nitrogen uptake, accumulation, and seed quality of oil peony].

Field experiments, including four levels of N application 0, 18, 24, 30 g N·m, were carried out to clarify the effects of nitrogen fertilization on N accumulation and translocation in lea-ves as well as the seed quality of oil peony (Paeonia ostii 'Fengdan Group'). The results showed that the nitrogen application significantly increased the height, canopy, flower diameter and flower dry mass. The heights under the treatments 24 and 30 g N·m increased by 14.